Vaccine Preventable Diseases in Indian Adults-Burden & Prevention

Adults are 60% of our population and the most economically productive age group. However, they often neglect their health while taking care of others. Waning immunity from childhood vaccines, change in target age groups for many Vaccine Preventable Diseases (VPDs), extensive travel, stressful lifestyles and neglect of prevention has led to the increasing burden of VPDs among adults. Gone are the days when vaccines were only for kids. In today’s fast paced world, where there is little time to fall ill, vaccinations are becoming imperative for adolescents and adults too. India has a large burden of these diseases and there are many roadblocks that hinder the path of tackling them. This commentary tries to throw light on this burden of diseases and various strategies that can be adapted to upscale adult vaccination in India.

There have been major epidemiological changes in the prevalence, affected age groups and susceptibility of infectious diseases. Many diseases once known to affect only children are now seen among adults as well. One such example was seen in former Soviet Union where a massive diphtheria outbreak caused more than 1,57, 000 cases and 5000 deaths. Surprisingly, majority of cases occurred in persons > 15 years old, and very high incidence and death rates was seen among adults from 40 to 49 years old [1]. A news report recently suggested that more than 95% deaths due to VPDs in India occur in adults [2]. Moreover, the morbidity and disability caused by VPDs in a country like India is also humongous [3]. Apart from the diseases that can be easily prevented through vaccines, there have been emergence and re-emergence of infectious diseases that has further pressurized our already overburdened health system. To name a few, HIV, malaria, multi-drug resistant Tuberculosis and drug resistant Sexually Transmitted Diseases (STDs) are posing a new challenge. In such a situation, more emphasis should be laid on tackling the VPDs that can easily be prevented through vaccination.
Vaccination is the most cost effective and powerful weapon of prevention. Vaccination is one of medicine's greatest accomplishments, reducing and in some cases eradicating once lifethreatening diseases such as smallpox and polio [4]. Gone are the days when vaccines were only for kids. In today's fast paced world, where there is little time to fall ill, vaccinations are becoming imperative for adolescents and adults too. Center for Disease Control (CDC) states "Traditionally, vaccines have been associated with protecting young children, but far too many adults become ill, are disabled, and die each year from diseases that could easily have been prevented by vaccines [5]." Adults are 60% of our population and the most economically productive age group. They often neglect their health while taking care of others. The immunity that children acquire because of vaccination wanes off as they turn into adults making them susceptible to diseases once again. If they acquire the diseases they not only lose some days of productive work but can also infect their little ones. Western world is aware and proactive.

Adult vaccination has many advantages like:
Reduced burden of diseases in the most productive group • Reduced incidence and prevalence of the disease in the popu-• lation owing to the herd immunity that adult vaccination will provide Vulnerable groups will have better protection if people around • are vaccinated-like infants, people with chronic diseases, pregnant females and elderly people However, despite of adult vaccination being such a costeffective strategy, there is no data on adult immunization coverage in India neither are there any recommendations in place and it is assumed that adult immunization is 15-20 years behind as far as large scale acceptance is concerned. There is no focus on adult immunization [7][8][9].

Burden of VPDs in India & Vaccinations Available
There are various diseases that cripple India's health system and VPDs are amongst them. India is a developing nation and deaths due to infectious diseases still surpass that due to non-communicable diseases. There is a lack of systematic epidemiological data defining the exact burden of various diseases. However, some sporadic and local data is available that has been summarized below.

Rubella
Congenital Rubella syndrome (CRS) is a big public health problem of India. It has been observed that around 40-45% of women in the childbearing age are susceptible to Rubella and over 2 lakh babies are born with birth defects because of Rubella infection during pregnancy in the Indian sub-continent [10]. CRS accounts for 10-15% of pediatric cataract. 10-50% of children with congenital anomalies have laboratory evidence of CRS. According to the Advisory Committee on Immunization Practices (ACIP), all females of childbearing age group should receive 2 shots of MMR vaccine if they are susceptible, at least 3 months before pregnancy. Susceptibility can be ensured by absence of immunization, absence of disease in the past and serological testing. However, serological testing is a costly procedure and requires two visits to the healthcare facility -one visit for testing and second for immunization thus immunization should be advised whenever immunity against Rubella is in doubt.

Cervical Cancer
Around 1, 32, 000 women in India each year are detected with cervical cancer and 74,000 of them die [11]. The cancer is the second most common cancer in India and has a high mortality (50%), mainly due to lack of awareness and no systematic screening infrastructure in place. The factors leading to high prevalence of cervical cancer in India are many. For e.g., genital hygiene standards are quite low. Of the 355 million menstruating women in India, only 12% use sanitary napkins [12].
Thus, in the present scenario, the best defense we have against cervical cancer is prevention through vaccination. Human Papilloma Virus (HPV) vaccines are two vaccines that have been developed against strain 16 and 18 of HPV that causes most of the cases of cervical cancer (76.7% of the cases in India [11]). HPV vaccines are licensed in 100 countries and are a part of school vaccination programs in 58 countries including the neighboring country Bhutan where the government is providing the vaccine free of cost to 6th grade girls and look to achieve an immunization rate of over 90%. It is high time that we stop ignoring this highly prevalent, deadly yet completely preventable cancer. The vaccine has to be delivered prior to exposure to the HPV virus as it is a prophylactic vaccine, therefore, the immunization must precede the sexual debut. Evidence suggests the age for initiation for vaccination to be 10 -12 years, however, catch up vaccination can be done till 26 years of age [1].

Hepatitis B
India is a country of high endemicity with 300,000 new Hepatitis cases occurring each year [13]. The number of HBsAg carriers in India has been estimated to be over 40 million and annually around 205,286 deaths related to chronic hepatitis occur [1]. Primary liver cancer, called heaptocellular carcinoma, is the fifth leading cause of cancer death in adults worldwide and third most common cancer in developing world settings [14,15]. Adults in high risk groups of acquiring Hepatitis B are healthcare providers, those who require frequent blood, injectable drug users, people having multiple sexual partners, men who have sex with men and household contacts of Hepatitis B patients or carriers. All children and adolescents younger than 18 years old and not previously vaccinated should receive the vaccine. Hepatitis B vaccination is also indicated for all unvaccinated adults at risk for HBV infection and all adults seeking protection from HBV infection including postexposure prophylaxis [1]. Three doses (for high-risk groups if not previously immunized) are recommended.
Even healthcare providers who are at such a high risk of acquiring blood-borne infections like hepatitis-B have a low coverage of Hep -B vaccination amongst them. A study by Singhal V et al [16] on 'Hepatitis B in Health Care Workers: Indian Scenario' has revealed that though healthcare workers are at a very high risk of acquiring the infection but only 50% have received a shot of hepatitis-B in Delhi. Also, the results cannot be extrapolated to other areas of the country.

Influenza
The burden of influenza or simply flu in adults is unimaginable as a study has revealed that during peak periods of influenza activity circulation i.e. during the monsoon period, 20% of all hospital admissions have influenza positivity [17]. Around 40,000 deaths occur due to Influenza annually [13] and the situation is grimmer when an epidemic or outbreak is there. A study from south India reported a monthly incidence of respiratory infections to be 23% in urban areas and 17.7% in rural areas among the pediatric age group [1].Children might be having the highest infection rate but persons aged over 65 years, young children and persons of any age who have some co-morbid medical conditions are at highest risk for complications, hospitalizations and deaths from influenza.
CDC recommends administering inactivated influenza vaccine to all persons 6 months of age and older annually, however Indian Academy of Pediatrics (IAP) has recommended seasonal influenza vaccine to high risk children and adults like people with chronic cardiac, pulmonary (excluding asthma), hematologic and renal (including nephrotic syndrome) condition, chronic liver diseases, diabetes mellitus, acquired immunodeficiency (including HIV infection) and laboratory personnel and healthcare workers.

Hepatitis A
The virus has a worldwide distribution and causes about 15 million cases of clinical hepatitis each year [1]. Studies in India have shown HAV sero-prevalence to be between 38% to 92% indifferent age groups [1]. Various findings have shown that a significant proportion of the Indian adolescent and adult population is at risk of Hepatitis A Virus (HAV) infection. A study showed an increased incidence of symptomatic HAV among children (10.6% to 22.0%) and also in adults (3.4% to 12.3%) amongst the patients with acute viral hepatitis attending a hospital [18]. Vaccine is specially recommended in high risk groups like international travelers, men who have sex with men, people with clotting factor disorder and persons with chronic liver disease.

Meningococcal disease
Several major epidemics of meningococcal disease have been reported, pre-dominantly from the major cities, and particularly from New Delhi. This distribution may be because of overcrowding, vulnerability to the new strains, or suitable climatic conditions. Routine vaccination of the population at large is not recommended except during epidemic situations. Also, Meningococcal vaccine is recommended to be given to Haj pilgrims and other travelers visiting the countries where meningococcal disease is a major problem or where outbreaks are occurring and high risk groups, e.g. children living in orphanages, jail inmates, soldiers in Barracks etc.

Chicken pox
Many studies have found out that though chicken pox is a disease of children but in tropical countries like India, the disease is common in adolescents and adults in whom it causes greater morbidity and mortality. Due to reasons not clearly known, the sero-conversion in tropical countries is low leading to such a disease trend. The bigger problem that India is facing is that due to these factors, a large proportion of women of childbearing age are susceptible to Varicella Zoster virus during pregnancy. They may pass the virus to their unborn child leading to congenital varicella syndrome in the child. Vaccination may limit the morbidity and mortality associated with adult and neonatal disease and helps to reduce the individual, social and economic incurred by this disease.

Shingles (Herpes Zoster)
Shingles is a painful and debilitating condition that occurs in elderly due to the chicken pox virus that lays dormant for years in the nerve roots of spinal cord after causing chicken pox in childhood. One-fifth of childhood chickenpox infection leads to shingles in old age. Thus it is important for people more than 60 years to get this vaccine.

Pneumococcal Disease
Preventable Invasive Pneumococcal Disease (IPD) includes meningitis, pneumonia and septicemia. They lead to great morbidity and mortality in all age groups worldwide. Around 85% of invasive pneumococcal disease occurs in adults. Among adults, with Community-Acquired Pneumonia (CAP) requiring hospital admission, S pneumonia ranks first as a cause and accounts for most of such cases. There are 155.8 million clinical episodes of pneumonia globally, which contribute to approximately1.9 million deaths, 70% of which occur in Africa and south-east Asia [1]. ACIP recommends pneumococcal vaccination for the following adults: Age 65 years and older, age 19-64 years of age with: asthma, diabetes, lung, heart, or liver disease, or alcoholism, cigarette smokers and residents of long-term or chronic care facilities (e.g., nursing homes). A 23-valent vaccine is recommended in adults and prevents about 60-70% of the invasive disease.

Citation: Rathi A, Sharma S (2017) Vaccine Preventable Diseases in Indian Adults-Burden & Prevention. Infect Dis Diag Treat 2017: J102
The various vaccinations for adults have been depicted in Figure 1.

Roadblocks in Adult Vaccination
The reasons for low adult vaccination coverage are many. Adults are busy and ignore their health status for too long. Many adults do not go to the doctor regularly, or do not have a primary care physician. They just visit a physician when they fall ill or things go out of hand. Their priority is mostly getting short-term relief and they do not think about long-term health gains. There is a major lacuna in adult awareness about vaccinations and adults think that vaccination is only for kids. In an unpublished survey, it was found that more than 80% of the adults being surveyed did not know about adult vaccination. Additionally, there are no recommendations of vaccinations by family physicians as they themselves have little awareness about the same. It is possible as there are no recommendations and guidelines for adult immunization in India and very few physicians recommend their adult patients any vaccines. There are lot of doubts in the minds of doctors and general public regarding the safety, efficacy and need of adult vaccines.

Way Forward
It has been more than three decades since Expanded Program on Immunization (EPI) was launched in India in 1978, and immunization has been further up scaled with introduction of Universal Immunization Program (UIP) in 1985. Since then, major strides have been taken to reach the vulnerable and eliminate the diseases. The infrastructure, manpower, and resources -all are in place and India should think of reaching the adults with vaccination too. The WHO scientific advisory group of experts (SAGE) to Global Program for Vaccines and immunization (GPV) has also indicated the need to expand immunization activities beyond infancy, either as part of routine immunization services, or as part of disease elimination and/ or eradication measures [1]. Efforts should be made to increase awareness about adult vaccination so that the demand for the same increases. Private and general practitioners should seek opportunities to make their patients aware about adult vaccination, as healthy adults are difficult to target and reach. Lessons can be learnt from successful vaccination program in which pregnant females have been immunized against tetanus. This has led to the successful elimination of neonatal tetanus in India. Such an organized approach should also be replicated for other vaccines for adults. Political will is very important for any health program to be successful, so the government should make adult vaccination a priority and should ensure uninterrupted funding for the same. Last but not the least, research and development is imperative and a proper surveillance system should be in place so that the missing data can be found and a more solid ground is laid for adult vaccination in the country.