Abstract

To investigate the effect of aseptic biofilm for improving the treatment of refractory post-traumatic wounds. From January 2020 to December 2021, 40 eligible patients with Refractory Post-traumatic wounds were admitted to the Department of Burn and Plastic Surgery of the First Affiliated Hospital of Soochow University in this retrospective analysis. 40 patients were assigned to the aseptic biofilm group. The aseptic biofilm group&rsquo,s operation was performed including the debridement, aseptic biofilm covering, and Vacuum-Assisted Closure therapy. Mesh gauze group&rsquo,s operation was performed including the debridement, mesh gauze covering, and Vacuum-Assisted Closure therapy. Skin grafting or skin flap transplantation was performed according to the condition of the wound. The time required for preparation of the substrate, VAS score during dressing changed, the time required for complete wound healing, the length of hospital stay, and cases with postoperative complications were recorded in this study. In this study, The time to wound healing and preoperative wound substrate preparation were significantly lower in the 20 patients in the aseptic biofilm group than in the petrolatum gauze group (t=-3.196, p<,0.05) (t=-2.520, p<,0.05). Pain scores during dressing changes were lower in the aseptic biofilm group compared to the mesh gauze group (p <,0.05). Aseptic biofilm has the characteristics of temporarily protecting the wound, promoting wound healing, shortening the time of preparing for operations.

Keywords: Aseptic Biofilm, Porcine collagen-based dressing, Refractory post-traumatic wound, Trauma, Wound healing