Iatrogenic Drug and Kidney Graft: About A Case
INH Bekhti, Bechir Ferchichi, N Amara, R Bouguesri, Sam Guelil, Zitouni Hannachi,
Mekaouche NFZ, Haxhi Ferati, Belbouche N, Muhammad Boudiaf, Houari Toumi*
Pharmacovigilance Service -Etablissement Hospitalier Universitaire-EHU d’Oran, Algeria
*Corresponding author: Houari Toumi, Pharmacovigilance Service -Etablissement Hospitalier Universitaire-EHU d’Oran, Algeria. Tel: +213041421579 ; Email: toumi54@live.fr
Received Date: 07 September, 2017; Accepted Date: 28 September, 2017; Published Date: 09 October, 2017
1.
Summary
1.
Introduction
One of the major problems of the chronic end stage of the renal failure diagnosis is that it can remain asymptomatic for a very long time, until a nearby DFG of 15 ml/min/1,73 m² of the body surface. It is often diagnosed in a very late stage in the disease evaluation [2].
The point of this work is to show the involvement of the Nonsteroidal anti-inflammatory drugs through the studies of indesirable effects of an unwanted circumstance at the EHU-Oran’s pharmacovigilance service during the aggravation of the chronic end stage of the renal failure.
2. Patients and Methods
The responsibility of AINS in the occurrence of the NIC is more or less
clear, heir administration on a chronic
basis over the years is responsible for serious chronic interstitial
renal parenchymal willingly complicated urinary tract infections, papillary
necrosis and very long-term tumor of urinary tract, it is true unknown abuse and triggered by painful
menstruation and/or frequent headaches
that reminds our case. It affects almost exclusively women [6,7].
Before prescribing, consider the risk of
gastrointestinal, cardiovascular risk and renal risk because AINS increase the
risk of fluid retention, may favor a small increase in arterial thrombotic risk
in case of prolonged use, are capable of inducing acute renal failure.
Do not overlook the herbal drugs that are active drugs
that can also produce side effects and even exhibit some toxicity.
Infectious causes |
Infectious stones Chronic urinary infection associated with an anatomical abnormality of the urinary tract Renal tuberculosis |
Urological causes |
Nephropathy of vesico-ureteral reflux, Chronic obstacle stones, adenoma or cancer of the prostate, bladder tumor (or the pelvis), retroperitoneal fibrosis; |
Metabolic causes |
nephrocalcinosis: distal renal tubular acidosis, primary hyperparathyroidism, hypercalciuria, primary hyperoxaluria ... Chronic hypokalemia; |
Toxic causes |
Medications: Lithium, cyclosporin A, nephropathy analgesic, Chronic lead poisoning and cadmium Chinese herbs nephropathy (aristolochic acid) Balkan endemic nephropathy (mycotoxin); |
Dysimmune causes |
sarcoïdose, Sjögren |
Hematologic causes |
tubulopathy myeloma, sickle cell anemia; |
Hereditary causes |
Autosomal dominant polycystic kidney disease, autosomal recessive polycystic kidney disease, nephronophthisis, cystic disease of the spinal cord. |
Table 1: Etiologies of chronic interstitial nephritis.
Risk factors related to drug |
Intrinsic nephrotoxicity Combination with other nephrotoxic drugs Dose and rate of administration unsuitable, prolonged duration of treatment; |
Risk factors related to the patient |
Age, Pre-existing renal insufficiency, Comorbidities (diabetes, heart failure, multiple myeloma) Fluid and electrolyte disorder ... etc. |
Table 2: Risk factors for nephrotoxicity [8].
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9. Recommendation ANSM, acceptable use of AINS, July 2013.