case report Methotrexate for the Placenta in situ in Advanced Abdominal Pregnancy: A Case of Remaining Intra-Abdominal Infection and Myelosuppression after Methotrexate Treatment
Authors: Muhuza Marie Parfaite Uwimana1, Zhaoxia Liang1,2, Menglin Zhou1,2, Zhengping Wang2, Xiaofu Yang2, Danqing Chen2*
*Corresponding Author: Danqing Chen, Obstetrical department, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Rd #1, Hangzhou, 310006, China
1Obstetrics and Gynecology at Women's Hospital, Zhejiang university School of Medicine, China
2Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Received Date: 03 March, 2022
Accepted Date: 08 March, 2022
Published Date: 11 March 2022
Citation: Uwimana MMP, Liang Z, Zhou M, Wang Z, Yang X, et al. (2022) Methotrexate for the Placenta in situ in Advanced Abdominal Pregnancy: A Case of Remaining Intra-Abdominal Infection and Myelosuppression after Methotrexate Treatment. Ann Case Report 7: 793. DOI: https://doi.org/10.29011/2574-7754.100793
Abstract
Advanced abdominal pregnancy is a kind of rare but life-threatening ectopic pregnancy, in addition to maternal and foetal safety until the birth, the placenta management after the foetus is out, is another challenge to obstetricians. Here we presented a 33-week primary advanced abdominal pregnancy case; the patient in this case experienced a laparotomy, which showed placenta adhesion to abdominal viscera, so the placenta was left in situ. Methotrexate was used to accelerate the degradation of the placenta, however, severe intra-abdominal infection and myelosuppression emerged soon, which had never been reported in similar published cases. It is still controversial whether methotrexate should be used for placenta management in advanced abdominal pregnancy, and the dose and frequency of this drug as well as patients’ condition should be comprehensively evaluated when methotrexate therapy is considered.
Keywords: Intra-abdominal infection; Methotrexate therapy; Myelosuppression; Placenta management; Primary advanced abdominal pregnancy