case report Paraneoplastic Amyotrophic Lateral Sclerosis in a Patient with Pheochromocytoma
Gift Echefu*, Sowbharnika Arivazhagan, Sai Samyuktha Bandaru, Catalina Negulescu
Baton Rouge General Hospital, 8585 Picardy Avenue, Baton Rouge 70809, LA, USA
*Corresponding author: Gift Echefu, Baton Rouge General Hospital, 8585 Picardy Avenue, Baton Rouge 70809, LA, USA
Received Date: 15 January 2023
Accepted Date: 19 January 2023
Published Date: 23 January 2023
Citation: Echefu G, Arivazhagan S, Bandaru SS, Negulescu C (2023) Paraneoplastic Amyotrophic Lateral Sclerosis in a Patient with Pheochromocytoma. Ann Case Report. 8: 1134. DOI:https://doi.org/10.29011/2574-7754.101134
Abstract
ALS is a progressive neurodegenerative disorder involving both upper and lower motor neurons. Paraneoplastic manifestation of ALS has been reported in association with certain cancers such as parathyroid hormone-related peptideinduced hypercalcemia, acromegaly, gynecomastia, gastric cancer. We present a 60-year-old male patient who was hospitalized multiple times for recurrent falls due to bilateral lower extremity weakness and painful muscle cramps. Physical exam findings revealed diffuse fasciculation is, atrophy and cramps suggestive of moto neuron disease. Work up revealed elevated 24 hours urine metanephrines and adrenal mass on abdominopelvic computerized tomography CT scan. He underwent laparoscopic resection of the tumour with histopathology confirming pheochromocytoma. Amyotrophic lateral sclerosis was later confirmed with nerve conduction study and electromyography.