Sílvia
Fernanda Cal1*,Cássio S Andrade2,
Brasil C3, Mittermayer B Santiago4
1Clinical Psychologist, Doctor and Master in Medicine and Human Health,
researcher at the Rheumatology Outpatient Clinic of the Escola Bahiana de
Medicina e Saúde Pública
(EBMSP), Brazil
2Psychologist, volunteer researcher at the Rheumatology Outpatient Clinic
of the Escola Bahiana de Medicina e Saúde Pública (EBMSP), Brazil
3Pysical Therapist, Master’s student in Medicine and Human Health of the Escola
Bahiana de Medicina e Saúde Pública (EBMSP), Brazil
4Adjunct Professor and Head of the Rheumatology Service of the Escola Bahiana
de Medicina e Saúde Pública
(EBMSP), Brazil
*Corresponding author: Sílvia Fernanda Cal,
Clinical Psychologist, Doctor and Master in Medicine and Human Health,
researcher at the Rheumatology Outpatient Clinic of the Escola Bahiana de
Medicina e Saúde Pública
(EBMSP),
Brazil. Tel: +557133412320; Email: silviacal@uol.com.br
Received
Date: 16 July, 2017; Accepted Date: 02 October,
2017; Published Date: 11 October, 2017
1. Introduction
Systemic Lupus Erythematosus
(SLE) is an autoimmune rheumatic disease of unknown causes [1,2] although psychological factors such as
depression anxiety and stress are known to play an important role in the etiology
and courseof SLE as well astreatment prognosis of the patient [3]. Depression is one of the most serious and common consequences
of chronic illness and is associated with an increase in morbidity and mortality
[4,5]. For the patients with SLE the depressive
disorder constitutes achallenge for psychological coping which are adjusting and
confronting systems that is a set of mechanisms that the organism resorts to in
reaction to stressors representing the manner in which each person evaluates
and deals with these aggressions [6]. This
challenge is due to the fact that there are many variables involved in the
symptom and severity patterns of SLE. The lack of a diagnosis is common and the
disease course is unpredictable [7]; on the
other hand, depression is not always diagnosed and treated adequately [8]. There is a relation between stress depression
anxiety and the physical manifestations of the disease such as rash, renal
function and levels of antibodies [9,10].
Depression and daily stress are known risk factors that may interfere in the
vulnerability of the lupus patients [11]
decreasing their Resilience Capacity (RS); that is their capacity to recover
and come out stronger when facing potentially traumatic life situations as in
the case of a chronic disease [12] and
situations known to be generators of stress associated with this condition.
Vulnerability includes physical and psychological factors with the biological
vulnerability referring to hypersensitivity of the limbic system, considered
the neural substrate of emotions, responsible for the changes in the Hypothalamic-Pituitary-Adrenal
axis (HPA) and showing an association with stress and depression [13,14]. The HPA axis is responsible in great part for
an organism’s response to a stressful stimulus. Stressors such as infection,
toxins and/or psychological trauma stimulate the HPA axis resulting in the
elevation of corticosteroids, suchas
glucocorticoid [15]. Many patients with
depression present a high concentration of cortisol (the endogenous
glucocorticoid in humans) in blood plasma, urine, and in the Cerebro Spinal Fluid
(CSF) an exaggerated response of cortisol to the Adrenocorticotropic Hormone
(ACTH), and an increase of the adrenal and hypophysis glands demonstrating the
association between depression and stress, although not all patients with
depression present these changes. Childhood adversity islinked to altered HPA
stress responses with an increased risk for multiple forms of psychopathology
conditions associated with suicide including schizophrenia and mood disorders.
Suicide is also strongly associated with a history of childhood abuse and neglect
[16,17]. Researches onepigeneticshave been associatingstressfulenvironmental factorswith
autoimmune diseases [18].One study found that
daily stress (Occurring in circumstances of low intensity but of high
frequency) could exacerbate the symptoms of patients suffering from lupus [19]. Daily stress is very common in SLE due to the
disease’s unpredictability the psychosocial implications that are involved the
physical changes and the comorbidity with psychiatric illnesses such as
depression and anxiety [20]. In a
cross-sectional study Dobkin (1998) showed the relation between daily stress
and the physical and mental health of patients with SLE [21]. Most studies evaluating stress in patients with
SLE were limited to addressing daily stress while this article
evaluates the stress experienced throughout life.
This work has the
objectives of (1) analyzing the association between RS and symptoms of depression and anxiety in
patients with SLE and (2) evaluating the association of trauma history with RS in these patients.
2. Methodology
This was a
quantitative cross-sectional study conducted in the Rheumatology outpatient
clinic of the EscolaBahiana de Medicina e SaúdePública (Bahian School of
Medicine and Public Health) with a group of patients diagnosed with SLE
according to the criteria of the American College of Rheumatology [22]. Patients between the ages of 18 and 65 were
included, selected through randomization and after agreeingto participate in
the study. The patients were selected through
randomization using a Random Number Table based on Stevenson 1981 [23].Randomization occurred by using on each day of consultations, a number
corresponding to the Random Number Table. The sum of this number was obtained
and the result corresponded to the number of the patient to be attended on the
medical appointment list. If this patient had any exclusion criterion a new
number was used from right below the name of this patient and the sum
corresponded to the next patient to be invited to participate in the study. Those
withother autoimmune
rheumatologic disorders whodeclined to participate or were unable to answer the
questionnaires were excluded from the study.
2.1. The following were used as
assessment instruments
Sociodemographic
questionnaires the Mexican version of the Systemic Lupus Erythematosus Disease Activity
Index-MEX-SLEDAI-where a medical resident carried out the patient evaluation
right after the scheduled appointment [24] Wagnild
& Young Resilience Scale [25,26,27] validatedfor
Portuguese by Pesce et al. (2005) [28] measured
levels of positive psychosocial adaptation in the face of adverse life events
(20); Hospital Anxiety and Depression Scaledeveloped by Zigmond andSnaithin
1983 [29] and validated by Botega et al., in
1998 [30] having 14 items 7 for anxiety 7 for
depression with a cutoff point of 8 for anxiety and 9 for depression and theTrauma
History Questionnaire Green (1996) [31] and
adapted for Portuguese byFizman et al. (2005) [32]
aiming at evaluating the occurrence of a wide variety of traumas of large
magnitude throughout life. The sample size calculation was carried out with
calculations fromthe Laboratory of Epidemiology and Statistics of USP (LEE) where the population ratio was 40% with absolute
precision of 10% significance level of 5% and a necessary sample of 92
volunteers. The data were analyzed using the SPSS (Statistical Package
for Social Sciences) version 19.0 for
Windows. Either Pearson’s chi square test or Fischer’s exact test was used to
evaluate associations between qualitative variables; a multivariate analysis
was used to calculate the prevalence ratio. The significance level adopted was
p < 0.05. The patients signed the Informed Consent Form where they agreed to
participate in the study and allowed the scientific use of the data. The Research
Ethics Committee (REC) of Santa Izabel Hospital approved the research protocol
(Approval Number 90/2012).
3. Results
Ninety-two
patients were included in the study, followed up at the outpatient clinic from
04/08/2013 to 07/14/2014. The selected sample was exclusively female which is
not uncommon when dealing with lupus for this population is predominantly
female andages rangedbetween
18 and 65 years (average age 36.83, standard deviation was 9.943, mean 36.00).
The most prevalent age group was between 18 and 30 years and 70% of them had a
partner (husband, partner or boyfriend). As to the socioeconomic evaluation 19
(21.3%) of the patients had a family income below minimum wage while 21(23.6%) had
a family income corresponding to the monthly minimum wage. Fifty-seven (62%) of
the patients did not hold a paying job (some were receiving benefits).
The association between resilience severity and
socioeconomic and clinical variables of the patients with lupus is listed in (Table 1).
3.1
Observation
R$724.00
corresponds to the monthly minimum wage at the time the study was conducted. With
regard to the clinical characteristics, the most prevalent time of diagnosis
was ≤ 4 years. A total of 55 (59.7%) patients
were taking corticoids. Based on the MEX-SLEDAI, 42 (45%) of the patients did
not present active SLE, and the rest had “Probably Active” 20 (21.7%) or “Active”
30 (32.6%) SLE.
The following results
were shown when evaluating the degree of RS in the studied population: Low RS
was identified in 17 (18.5%) cases (score <120) moderate RS in 56 (60.9%) (Scores
between 121-145) and high RS in 19 (20.7%) (Score>145). In this study the
classification of RS scores was grouped into “Low” and “Medium/High.” In the
assessment of depression symptoms in the patients with SLE 23 (25%) presented these symptoms. With regard
to anxiety, 47 (51.1%) presented such symptoms. In the
association between RS and clinical variables significance between the
variables “Resilience” and “Depression” and “Resilience” and “Anxiety” was
observed, therefore one can say that the patient who does not have depression
tends to have a higher scoreof
RS. The same occurs in the association with anxiety. There was no significance
for the variables “Disease activity” “Use of Corticoids” and “Time of Diagnosis.”
With regard to exposure to traumatic events 16 (17.4%) of the patients suffered
sexual violence; nine of whom were children at the time.
The abusers were family friends, cousins, neighbors, stepfathers, or uncles.
Only two cases involved men who were not relatives; one was a stranger and the
other was the father’s employee.
The prevalence of
those who experienced non-sexual violence was 55 (59.8%) where the most common
was robbery reported by 30 (32.6%) and robbery with force or threat by 25
(27.2%) followed by physical violence (beating, pushing, striking and causing
lesions) reported by 14 (15.2%) patients. With regard to childhood sexual
violence only 9 patients had gone through this situation. Among these only 2
did not present marked symptoms of depression and anxiety. The ones who were
abused by their step father, uncle, or family friend presented symptoms in the
range of strong anxiety and/or strong depression. There was no statistical
significance found in the study of an association between RS and history of
trauma (Table 2).
Using the
multivariate analysis to identify the variables associated with low RS,
depression was the only significant variable (Table 3).
4. Discussion
The results of
this study indicate that scores of low RS are associated with depression which
is in agreement with previously published studies that confirm an inverse
relation between depression and anxiety and RS both with regard to SLE and to
other clinical conditions [11,33-37].Therefore
it could be said that high scores of RS might protect against the development
of psychiatric illnesses so prevalent in chronic conditions [38,39] and that are so harmful to the patient’s
quality of life related here to the impact that the disease and its treatment
have on the individual’s ability to function and his or her perception of
well-being in the physical, mental, and social domains [40].
In this study in agreement with previous studies [38,39]
prevalence was found of anxiety symptoms (51.1%) even more than those found for
the variable depression (25%). It is known that there is an association between
anxiety and RS confirmed at the beginning of the study analysis when the data
were evaluated through chi-square but it was not confirmed in the Poisson
regression. Despite this and even due to the fact that anxiety is the main
comorbidity of depression one can understand anxiety as a risk factor for low RS. Clinical variables such
as time of diagnosis, corticoid use and disease activity were not associated
with a lower or higher score of RS findings that were similar to a previousstudy
conducted at our service center [9]. Abu-Shakra
(2016) similarly did not find any association between RS and disease activity.
To said author depression is associated with the subjective experience of the
disease and not the disease itself or the disease activity [41] while Schatner (2010) considers the disease
activity a predictor for depression in lupus [7].
Among the sociodemographic variables, the only one that reached statistical
significance in association with RS although unconfirmed in the Poisson regression
was education. Changes are fast and constant in modern life demanding
continuous effort to adapt which causes RS to be a great challenge seeing thatRS
entails variables and processes where human abilities support each other, to be
used when facing adversities that everyone comes up against in higher or lower
intensity [42]. The patient with lupus lives
with daily stress related to his or her chronic condition and all the
interfaces already reported in the body of this review. Depression is often
confused with stress due to hyperactivity of the HPA axis which makes the
differential diagnosis quite difficult. Depression as a symptom of stress is related to the
conditions of adaptation of the moment [14,43]. The
vulnerability model is directly related to the individual’s sensitivity to
emotional stress; certain traits may be developed to serve as buffers which make
a synthesis between biological vulnerability and stressful life events [43]. The literature has shown that maltreatment in
childhood and/or adolescence, concurrently or individually is associated with
mental, physical and behavioral disorders [44,45]
such as Attention-Deficit/Hyperactivity Disorder (ADHD) [46] cognitive disorders and somatizations [47]
history of alcohol abuse or dependence, depression, anxiety, Post Traumatic Stress
Disorder (PTSD) and the increase of inflammation measured by inflammatory
markers such as Inter Leukin 6 (IL-6), C-Reactive Protein (CRP) [48 as well as self-injurious behavior [49].
Sexual abuse is
the type of maltreatment that exerts the strongest association with mental damage
[50, 51]. Children who suffer various forms of
abuse may experience increased intensity of the harmful effects of these
traumas. In these cases comorbid symptoms frequently occur [52]. This study found that seven of the nine patients
who suffered childhood abuse by close relatives presented strong symptoms of
depression and anxiety in which case the traumatic experience becomes a risk
factor for low RS. However statistically speaking the variable “History of Trauma”
was not significant in association with RS perhaps due to the instrument that
was used. A qualitative methodology might lead to different results. Health
promotion and disease prevention are priority issues in present-day societies.
For Yunes (2003), Yunes and Szymanski (2001) the protective factors are the
true determinants of RS which would be the product of these factors of
protection [53,54]. For Rutter (1987) the
processes of protection are characterized by fostering modification of the
individual’s responses to the processes of risk [55].
According to Slap (2001) each person should be able to recognize his or her own
resources and should learn how to manage them and know how and when to apply
them [56]. The development of resilience
capacity and the promotion of resilient practices require different strategies
in the way of mobilizing and activating capabilities that will help onedeal with adversity in order
to overcome them, resulting inthe person beingstrengthened and even transformed.
The results of
this study leave no doubt as to highlighting psychological intervention as an
indispensable tool in the treatment of SLE. According to Córdoba-Sánchez and Limonero-García (2015) an effective psychological intervention (Be
it in a psychotherapeutic support group, psychotherapy combined with
psychoeducation cognitive behavioral therapy or a psychosocial group) along
with medical treatment for patients with SLE might promote active coping
mechanisms. These interventions should integrate components of psychoeducation
regarding the disease, support, and strategies for self-regulation, as well as a focus on self-efficacy and
self-esteem and the strengthening of a social support network [57]. Psychological assistance may be beneficial in
the sense of fostering greater adaptation to the disease, decrease of pain and improvement
ofthe clinical picture treatment adherence coping strategies lessening
depression and anxiety changes in self-esteem and quality of life all of which
influence the course of
the disease. Once the situation of stress due to previous trauma is identified and
afterthere is a resignificationof
this situation a new future is unveiled; the book of life may be written
differently and this includes health.
5. Limitations of This Study
Among the
limitations of this study is the fact that there were no male patients included
which occurred because of the randomization and the fact that the number of men
with lupus is much lower with a ratio of one man to ten women. Conclusions and practical implications:
The prevalence of depressive symptoms in patients with SLE using the HAD scale
was 25% and 51.1% for anxiety symptoms. Depression is the main factor associated
with low RS in SLE patients which may influence the onset and course of the
disease and intensify the vulnerability of the patient. For future research a
perspective of a deeper understanding between lupus and history of trauma is
suggested mainly regarding the person’s age at the time of trauma, for it is
known that potentially traumatic situations experienced in childhood may play
an important etiological role. Study
projects are necessary that include psychological assistance to the
patient with lupus at outpatient clinics as well as theeffort to make both patients and doctors aware
of the implications of emotional aspects on health.
6. Conflicts of
Interest: None
7. Acknowledgments
SFC
received a grant (number 0559/2012) from the Research Support Foundation
of Bahia and MBS received a grant from the National Council of Scientific and
Technological Development (Fundação do Amparo à Pesquisa
da Bahia and Conselho Nacional de DesenvolvimentoCientífico
e Tecnológico (CNPq).
|
Resilience (%)
|
|
|
Variables
|
n=92
|
Low
|
Med
|
High
|
|
Age (Years)
|
≥ and ≤ 30
|
3 (17.6)
|
24 (32.0)
|
|
|
> 30 and ≤ 36
|
3 (17.6)
|
18 (24.0)
|
0.456
|
|
> 36 and ≤ 44
|
6 (35.3)
|
16 (21.3)
|
|
|
> 44
|
5 (29.4)
|
17 (22.7)
|
|
|
Education
|
Primary
|
8 (47.1)
|
14 (18.7)
|
|
|
High School
|
7 (41.2)
|
50 (66.7)
|
0.045*
|
|
College
|
2 (11.8)
|
11 (14.7)
|
|
|
Have partner
|
No
|
6 (35.3)
|
21 (28.0)
|
0.565
|
|
Yes
|
11 (64.7)
|
54 (72.0)
|
|
|
Occupation
|
No
|
7 (41.2)
|
50 (66.7)
|
0.059
|
|
Yes
|
10 (58.8)
|
25 (33.3)
|
|
|
Family income (R$)
|
<724,00
|
4 (25.0)
|
15 (20.5)
|
|
|
724
|
6 (37.5)
|
15 (70.5)
|
|
|
>724,00 and<1500,00
|
3 (18.8)
|
!8 (24.7)
|
0.541
|
|
>1500,00 and<3000,00
|
2 (12.5)
|
20 (27.4)
|
|
|
≥ 3000,00
|
1 (6.2)
|
5 (6.8)
|
|
|
Religion
|
Catholic
|
6 (35.3)
|
31 (41.3)
|
|
|
Evangelical
|
11 (64.7)
|
29 (39.7)
|
|
|
Spiritist
|
0 (0.0)
|
3 (4.0)
|
0.224
|
|
Other religions
|
0 (0.0)
|
2 (2.7)
|
|
|
No religion
|
0 (0.0)
|
10 (13.3)
|
|
|
Time of diagnosis
|
<4
|
5 (29.4)
|
24 (32.0)
|
|
|
>4 and ≤8
|
0 (0.0)
|
19 (25.3)
|
0.075
|
|
>8and≤12
|
7 (41.2)
|
16 (21.3)
|
|
|
>12
|
5 (29.4)
|
16 (21.3)
|
|
|
Mex Sledai
|
<2
|
7 (41.2)
|
42 (56.0)
|
|
|
≥2
|
5 (29.4)
|
8 (10.7)
|
0.13
|
|
>5
|
5 (29.4)
|
25 (33.3)
|
|
|
HAD Depression
|
No
|
6 (35.3)
|
63 (84.0)
|
0.000*
|
|
Yes
|
11 (64.7)
|
12 (16.0)
|
|
|
HAD anxiety
|
No
|
3 (17.6)
|
42 (56.0)
|
0.006*
|
|
Yes
|
14 (82.4)
|
33 (44.0)
|
|
|
Use of corticoids
|
≤ 20mg
|
9 (52.9)
|
28 (37.3)
|
|
|
≥ 20mg
|
7 (41.2)
|
44 (58.7)
|
0.337
|
|
> 20mg and ≤ 40mg
|
0 (0.0)
|
2 (2.7)
|
|
|
>40mg
|
1 (5.9)
|
1 (1.3)
|
|
Table 1: Distributionof the populationacording to the degree of resilience inpatients with SLE.
Variables
|
Resilience n(%)
|
|
|
|
Low
|
Med./High
|
p
|
Non-sexual violence**
|
|
|
|
No
|
6 (35.3)
|
31 (41.3)
|
0.786
|
Yes
|
11 (64.7)
|
44 (58.7)
|
-
|
Sexual violence**
|
|
|
|
No
|
14 (82.4)
|
62 (82.7)
|
1.000
|
Yes
|
3 (17.6)
|
13 (17.3)
|
-
|
Exposed to radioactivity**
|
|
|
|
No
|
16 (94.1)
|
68 (90.7)
|
1.000
|
Yes
|
1 (5.9)
|
7 (9.3)
|
-
|
Suffered serious accident**
|
|
|
|
No
|
17 (100)
|
4 (5.3)
|
1.000
|
Yes
|
0 (100)
|
71 (94.7)
|
-
|
Participated in combats**
|
|
|
|
No
|
17 (100)
|
74 (98.7)
|
1.000
|
Yes
|
0 (0.0)
|
1 (1.3)
|
-
|
Natural disasters**
|
|
|
|
No
|
16 (94.1)
|
64 (85.3)
|
0.454
|
Yes
|
1 (5.9)
|
11(14.7)
|
-
|
Other traumas**
|
|
|
|
No
|
13 (76.5)
|
55 (73.3)
|
1.000
|
Yes
|
4 (23.5)
|
20 (26.7)
|
-
|
Witnessed or received
news of harm to others**
|
|
|
|
No
|
2 (11.8)
|
13 (17.3)
|
1.000
|
yes
|
Yes
|
15 (88.2)
|
62 (82.7)
|
-
|
Table 2: Association between resilience and traumatic events of the patients with Systemic Lupus Erythematosus.
Variables
|
Exp(B)
|
p
|
|
Final
Exp(B)
|
p
|
|
CI
|
95%
|
High school
Education
|
0.428
|
0.304
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PrimaryEducation
|
0.863
|
0.859
|
|
|
|
|
|
|
|
Depression
|
3.252
|
0.040
|
|
5.500
|
0.001
|
|
2.034
|
|
14.872
|
Anxiety
|
3.318
|
0.085
|
|
|
|
|
|
|
|
Table 3: Poisson regression analysis to evaluate variables associated with low scores of RS. Exp (B): regression coefficient, p: level of significance, CI: confidence interval.
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