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Vitamin K and its Role in Diabetic Vascular Complications and Low-Grade Inflammation

Sofia Dahlberg1,2, Ulf Schott1,2*

1Department of Anaesthesia and Intensive Care, Institution of Clinical Science Lund, Medical Faculty, Lund University, Sweden

2Department of Anaesthesia and Intensive Care, Skåne University Hospital Lund, Lund, Sweden

*Corresponding author: Ulf Schott, Department of Anaesthesia and Intensive Care, Skåne University Hospital, Lund, S-22185 Sweden and Institution of Clinical Science Lund, Medical faculty, Lund University, Sweden. Tel: +4646171319; +4646171000; Fax: +464617605; Email: ulf.schott@skane.se

Received Date: 12 December, 2017; Accepted Date: 16 January, 2018; Published Date: 24 January, 2018

Citation: Dahlberg S, Schott U (2018) Vitamin K and its Role in Diabetic Vascular Complications and Low-Grade Inflammation. J Diabetes Treat: 138. DOI: 10.29011/2574-7568.000038

1.      Abstract

This review summarizes the involvement of vitamin K and the extrahepatic Gla proteins matrix Gla protein (MGP), Osteocalcin (OC) and growth arrest-specific gene 6 protein (Gas6) in the development and progression of diabetes: in particular, complications related to angiopathy and inflammation. High vitamin K intake has been associated with a decreased risk of type 2 diabetes. Furthermore, in type 2 diabetic patients, the extent of artery calcification correlates to levels of the uncarboxylatedGla protein MGP, and supplementation with vitamin K has been shown to reduce oxidative stress markers as well as metabolic risk markers for diabetes.

2.      Keywords: Diabetes; Gas 6; Inflammation; MGP; Vitamin K; Vascular Disease




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