Advances in Biochemistry and Biotechnology (ISSN: 2574-7258)

Article / review article

"Algal Resources Exploitation for Green Economy and Sustainable Development: A Review"

Emmanuel Manirafasha1,2*, Andrew Vajhuabmuas Vangh3, Theophile Murwanashyaka1,4, Benoit Rugabirwa1, Theoneste Ndikubwimana5, Godelieve Mukagatare6, Jean Damascene Ndayambaje1, Li Guo1, Liang Shen1, Xianhai Zeng7, Keju Jing1*, Marcellin Rutegwa2,8, Yinghua Lu1*

1Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, and The Key Lab for Synthetic Biotechnology of Xiamen City Xiamen University, Xiamen, China

2University of Rwanda-College of Education, Kigali, Rwanda

3China International Water Law (CIWL), School of Law, Xiamen University, Xiamen, China

4Kibogora Polytechnic, P.O.Box 31 Rusizi, Rwanda

5Head of Academic Quality, Accreditation, Standards and Qualifications Framework Department, Higher Education Council (HEC), Kigali, Rwanda

6Department of Occupational and Environmental Health, School of Public Health and Health Management, Chongqing Medical University, Chongqing, China

7College of Energy, Xiamen University, Xiamen, China

8Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Institute of Aquaculture and Protection of Waters, the University of South Bohemia in České Budějovice, Husova tř. České Budějovice, Czech Republic.

*Corresponding author: Yinghua Lu, Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, and The Key Lab for Synthetic Biotechnology of Xiamen City Xiamen University, Xiamen 361005, China. Tel: +86-5922186038; Fax : +86-5922184822; Email: ylu@xmu.edu.cn

*Keju Jing, Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, and The Key Lab for Synthetic Biotechnology of Xiamen City Xiamen University, Xiamen 361005, China. Email: jkj@xmu.edu.cn

*Emmanuel Manirafasha, Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, and The Key Lab for Synthetic Biotechnology of Xiamen City Xiamen University, China. The University of Rwanda, College of Education, Kigali, Rwanda. Email: meonb2003@gmail.com

Received Date: 13 May, 2019; Accepted Date: 03 June, 2019; Published Date: 11 June, 2019

Introduction

At the center of the green economy and sustainable development are human beings and their entitlement to a harmonious, healthy, and productive, life with nature [1]. Human health and quality of life are confronted with various harsh conditions, including climate change, burden illness, antibiotic resistance, and the side effects of medication, among others. Chronic diseases, malnutrition, and antibiotic resistance are the pressing global health challenges, which are the important cause of illness, disability, and death while there are some possibilities to prevent them [2]. There is also an imbalance between available natural resources and global population growth as more demands are placed on natural resources to meet human needs. This gap is further aggravated by climate change effects where nonrenewable resources are being depleted, and arable soils are becoming infertile, as well as other related challenges [3]. Apart from hampering human health, the quality of life is also negatively affected, especially global sustainability and development because the green economy and sustainable development cannot be discussed without food security and nutrition that have concomitant relation with longevity and quality of life.

In order to achieve harmony, the global community has set several goals in which healthy human populations, sustainable development, and the green economy are linked. In 2012, the international community reaffirmed its commitment to sustainable development and past action plans with the outcome document “The future we want” at the United Nations Conference on Sustainable Development (SD) in Rio de Janeiro [4] which was endorsed by the United Nations General Assembly shortly after [5]. The Food and Agriculture Organization of the United Nations (FAO) has the goal of achieving zero hunger, food security and improved nutrition by 2030 (SD-goal 2), and good health and well-being (SD-goal 3) that may contribute to the promotion of human health and quality of life [6]. Nevertheless, the World Health Organization (WHO) reported that prevention of chronic diseases is a vital investment as chronic diseases, especially cancer and diabetes, will keep increasing within the same range of time and new cancer cases will increase in number up to 22 million within the next 20 years worldwide [7,8]. Among the many avenues to achieve these global goals is through scientific research and application to satisfy daily needs and future development [9].

This article highlights some global challenges hindering the achievement of sustainable development and describes algal resources inputs in the resolution of these pressing global challenges and achieving sustainable development. Natural resources are continuing to be depleted while the global population continues to increase [10]. This imbalance is the reason why researchers are interested in the exploitation and management of renewable natural resources for future betterment.

Nutrient-rich foods (with all essential nutrients), also termed as rainbow food or complete food, help prevent and control various diseases due to their physiological activities. Taking daily complete food can improve the self-protection and self-healing capacity of the body, thus leading to a healthy body [11].

Referring to the available scientific literature, and some algal derived products available on the global markets with prominent health promotion; algal resources are one of the potential natural sources of food with essential nutrients [12], that can contribute to the achievement of the availability of nutrient-rich foods with health benefits, and zero hunger goal (Figure 1). Algal resources are considered one of the promising and sustainable resources to be exploited in various industrial fields [13], due to their enormous biochemical composition including essential nutrients, functional ingredients of food and pharmaceuticals [12]. Algal resources exhibit several advantages (see Supplementary Material S1) that makes them part of the plausible inputs to achieve sustainable development [14].

Because of the mentioned advantages and potential, algal resources have mesmerized the attention of many researchers for their amply exploitation and utilization in resolving some life challengesThe integration of algal-derived functional foods and nutraceuticals in food security and nutrition would be considered as one alternative intervention to promote human health and quality of life.

As far as the authors are aware of algal resources exploitation and sustainable development goals, no other articles are summarizing the integration of algal resources in the whole systems for human well-being and sustainable development. Therefore, this review article focusses not just on the efficacy of algal-derived functional foods and nutraceuticals for a healthy life but it also highlights other opportunities in the exploitation of algal resources that can contribute to the achievement of sustainable development and green economy.

Challenges Hindering Sustainable Development Achievement

Various global challenges hinder the achievement of sustainable development goals. Some of those challenges linked to climate change and malpractice of agriculture are food security and nutrition, chronic diseases, and antibiotic resistance. Climate change and conflict zones may be considered as leading causes of food insecurity, which subsequently lead to inadequate living conditions. Climate and environmental change are also behind infectious and non-communicable diseases and malnutrition [15]. The latter three main challenges are somehow interconnected and interdependent. For example, antibiotic resistance has one of the roots associated with food production because of the overuse of antibiotics in livestock as a growth promoter and disease preventer [16]; and water resources contamination with waste-derived fertilizer residues because of its overuse [17] (Figure 2).

Also, the imbalance between global population growth and available resources cannot be ignored. Unsafe lifestyle and diet related-diseases including diabetes are also a problem among current global health challenges that are causing disabilities and deaths (For detailed information, about the challenges and current strategies and policy, see supplementary material S1).

Current global population growth raises and imposes the need for an integrated and sustainable food policy [18]. That policy should provide technologies and knowledge about complete healthy food production, which aims to promote health and help prevent disease and a reduced risk of diet-induced diseases. The complete healthy food contains nutrients and other substances (such as phytonutrients, omega facts acids, pre- and probiotics) that not only nourish the body but also promote human health and protection from health-related problems, including chronic diseases (Figure 3). Therefore, there is a critical requirement for the promotion of sustainable and supportive food sources for agricultural foods to tackle undernourishment and achieve food security and nutrition

Why are algal resources plausible inputs for achieving sustainable development and the green economy?

Natural resources are continuing to be depleted while the global population increases. This is the reason why the researchers are fully interested in the exploitation and management of renewable natural resources for future betterment. The algal resource can produce feedstocks with a broad range of compounds that can be applied in food, feed, pharmacy, cosmetics, biofuels, and biotechnology industries, to mention just a few [19, 20]. Based on the several advantages associated with algal resources including eco-friendliness, high efficiency (as detailed in S1); utilization of algal resources can contribute to a green economy and sustainable development through the promotion of human welfare and quality of life [21] (Figure1).

Algal resources (i.e., microalgae, macroalgae, and cyanobacteria) are many species [22] with different genetic, morphological and physiological characteristics that confer the ability to produce many bioactive compounds with several biological [23], and pharmacological activities [24,25] that can be exploited in various industries. The composition profiles of algal species have attracted many researchers from prestigious research centers and high-ranked universities for their exploration. The selection of algal species/strains and culturing modes depend on the compounds of interest and utilization of produced biomass [26] (Figure 4). For example, Spirulina sp., Chlorella sp. Anabaena sp., Nostoc sp. are recognized for bioactive substances that are mainly applied in food, health food, nutraceutical, and pharmaceutical fields due to their functional food, physiological, and pharmaceutical properties [27]. Botryococcus braunii is recommended for biofuel production due to its high lipid content ( up to 78%) [28].

Algal derived products also play an important role in the world economy [14], wherein 2001 the turnover was approximated to US$ 5 billion per year [29], and continues to increase: currently, the algal-based nutraceuticals market is estimated to have reached about US$ 2.5 billion by 2018. According to Global Algae Products Market 2017-2022 report, the market is expected to increase up to US$ 3.3 Billion by 2022 [30].

Algal derived foods, health foods, nutraceuticals and their input in human health and food security and nutrition

Algal derived foods are one of the most nutrient-rich food sources for new sustainable food and functional food products due to their high growth rate, high productivity, and macro- and micro-nutrients with many health benefits [31,32]. They can be used to enrich the nutritional value of foods and in return, promote health due to their well-balanced chemical composition, especially bioactive compounds with prominent benefits for animal and human health [33]. For instance, the nutritional values of algal resources are higher compared to a fish meal because they contain digestible complete proteins, lipids, and carbohydrates, as well as micronutrients [34]. The algal derived foods, especially Spirulina, have been traditionally considered and utilized as a potent source of proteins for many years in some countries, including Japan, Chile, and North America [35]. Recently, scientific studies show that algal resources are an adequate and sustainable source of bioactive molecules, especially for enhancing the nutritional and functional quality of foods [36].

The algal species that are commonly used in food, health foods, food supplements, and nutraceutical fields are Spirulina platensis, Chlorella vulgaris, Daniella salina, Aphanizomenon flos-aquae, Schizochytrium, and Haematococcus pluvialis [37] but Spirulina and Chlorella are most prominent due to available extensive research, and a wide range of compounds, especially proteins, that are applied in the food and medicine industries as healthier food products [35,37]. Spirulina is the most well-known and applied due to its macro- and micro-nutrients with health benefits (Figure 5) including complete and digestible proteins with all essential amino acids and non-essential amino acids, fatty acids, vitamins and minerals [36,38]. Chlorella is also a potent asset in human health and nutrition due to nutritional contents where it can lower oxidative stress, boosts the immune system, and health-promoting factor by controlling other kinds of disorders such as wounds, constipation, and anemia, among others [39].

The food industry has to keep exploiting the potential of algal-derived products as prominent sources of health-promoting products [36,40]. Based on tangible results from scientific research studies, global demand for algal-derived foods is growing, and their demands have been increased due to their functional benefits [35]. The algal derived functional foods, and nutraceuticals can be an adequate and sustainable supportive food source with components of the human diet that can reduce the risk of diseases and promote human well-being as well as livestock welfare. Therefore, the algae-derived products can be used for fortification of conventional foods with the cost-effective process [41,42].

The algal derived foods’ health benefits are also associated with their nature and characteristics. 1) Algal derived foods are alkaline foods, which are needed by the human body at a rate of 80 %, and some of them exhibit high digestibility (83-90%) [32]. 2) Algal resources are not only producing essential nutrients (i.e., proteins, fats, polycarbohydrates, minerals, vitamins) but also produce many other bioactive compounds such as Superoxide Dismutase (SOD), phycobiliproteins, carotenoids, flavonoids, glucosides, terpenoids, Polyunsaturated Fatty Acids (PUFAs) (including Docosahexaenoic Acid (DHA), Linolenic Acid (GLA) and Eicosapentaenoic Acid (EPA)) and phenazines among others [32,37]. These bioactive compounds are irreplaceable ingredients in the food industry, as well as other fields, due to various physiological, therapeutic and pharmacological activities that can prevent and control various diseases related to diet-induced, cell damage diseases and improving the quality of life.

Most diseases are linked to cell damage and malfunction such as cell deficiency in nutrient energy, cell inflammation, cell dysfunction, and cell toxicity [43]. Those cell problems, in turn, can lead to pre-mature cell-aging. The algal derived compounds are among promising bioactive compounds that can prevent cell damage and malfunction where those compounds can act as an antioxidant, anti-inflammatory, and antimicrobial, as well as release the side effects of free radicals in the human body [14,24,44]. Niu, Zhou, Guo, Nie, Shin, Kim, Lv and Cui [45] reported that phycocyanin could protect against mitochondrial dysfunction and oxidative stress in parthenogenetic porcine embryos. Lycopene, also known as phytonutrient, is a phytochemical with antioxidant activity that belongs to the group of carotenoid pigments. It helps protect cells by neutralizing free radicals, and it can positively affect the immune system, as well as other health benefits [46]. The consumption of a diet rich in antioxidant lycopene may help prevent and control various kinds of cancers such as prostate, breast, stomach, throat, and lung cancers in the human body [47], as proven in animal models [48]. SOD is a potent antioxidant enzyme, which plays a role in eliminating toxins in the human body, [49]. Astaxanthin, lutein, Zeaxanthin are carotenoids that can act as free radical scavengers and can also intervene in boosting visual and healthy immune functions by reducing eye irritation, fatigue and improve the quality of vision [11,50,51]. Food with PUFAs ω-3 and ω-6 compounds possess well-documented improving human health, protecting, controlling, and healing properties against various diseases, including chronic diseases [31,52]. It is in this line that microalgae as a prominent source of long-chain polyunsaturated fatty acids, including omega-3 and omega-6, and other nutritional compounds, are considered as prominent and sustainable foods for humans.

Probiotics are a heterogeneous group of non-pathogenic bacteria that help the body to absorb important nutrients (including vitamins and minerals) for body function, growth, and maintenance, thus leading to a healthy body [53,54]. Algal resources are among promising prebiotics that helps promote the proliferation of probiotic in the gut, thus leading to the promotion of human body immunity through different metabolic mechanisms. The dietary components, including nutrients and phytochemicals, are also regarded as dietary interventions in the perspective of cancer chemoprevention [55] where algal resources can play a vital role as sources of those nutrients and phytochemicals. Nutritious and health food promotes human health, and in return will reduce antibiotic prescription, which is one way of antibiotic resistance development (see Supplementary Material S1).

Different companies worldwide are currently considering the importance of algal-based resources and are trying to utilize them for high-value food products different from tablets, capsules, and powders, to minimize the negative connotation regarding algal derived foods, which in return can boost the exploitation of algal resources in the food industry. For example, a Dutch company launched dark chocolate containing 3 g of Spirulina [56]; Iranian Scientists produce sweets for people with diabetes using Stevia and Spirulina [57]. Furthermore, algal-derived products are used to fortify foods such as snacks for enhancing nutritional content [58,59]. This process of enrichment of foods should also consider sensorial characteristics, including color, flavor, taste, and texture that could increase the customer’s intention of acceptance and purchasing [59].

Algae for Pharmaceutical and Therapy

Antibiotic resistance and cancers are a growing health problem worldwide that urgently needs the formulation and production of new drugs and the provision of other means of prevention and control. Those new drugs should be effective in treating new diseases causing infections. Generally, natural products are a prominent source of new structures leading to drug formulation and production for most diseases. It is promising that algal derived bioactive compounds can also contribute to the development of new therapeutic and drugs development because the therapeutic effects of natural product-derived drugs are preponderantly achieved in antibiotic therapies and immune regulation [25]. Based on the tremendous algal derived bioactive compounds with several pharmacological and biological functions [24,60,61] including antibacterial, antimicrobial, anti-inflammatory, antiviral, anticancer, immunomodulating, antihyperlipidemic, antioxidant, antiallergic, and antiprotozoal [62-65]. It is in this sense that algal resources are a sustainable source of ingredients to be exploited in the pharmaceutical industry [66]. The fact that algal resources are very prolific and synthesize biologically active compounds like drugs have exhibited auspicious and plausible results through animal and clinical tests for various dreadful human diseases [65]. Therefore, algal resources are natural resources that provide a promising opportunity for new drug discovery for therapeutic entities [25,61].

Furthermore, algal-derived products can also promote human health while they are taken in their raw states such as Spirulina and/or Chlorella powders, tablets, and capsules. For example, Chlorella (also known as a detoxifying agent), which is rich in Chlorophyll, lutein, beta-carotene and Vitamin E, is known to provide several health benefits such as strengthening the immune system, lowering the oxidative stress and enhancing anti-tumor immunity [52]. Researchers from innovative cancer therapy of Kureme University, Japan and Chlorella Industry Co., Ltd., conducted a study for the quality of life in Breast Cancer patients (forty-five female patients in three groups randomly assigned) by using Chlorella extract drink, chlorella granules, and vitamin mix tablet as control within a period of one month. The study concluded that Chlorella hot water extract has positive effects on breast cancer patients. Those positive effects are a reduction of fatigue, improvement of abdominal symptoms, improvements of dry skin, improvement of hair gloss and improvements of the cold constitution, while the control group did not exhibit any positive effect [67]. Furthermore, most breast cancer patients have a major issue of stress, and Chlorella helps in managing the psychological distress in them.

Therefore, the novel studies in the development of new pharmaceutical agents, their pharmacokinetic, and metabolism as before clinical trials must be performed to the algal derived biologically active compounds. The clinical studies are then needed for promoting the utilization of algal-derived drugs as potential pharmaceutical agents to fight against the new diseases causing infections.

Algae for aquaculture, animal feeds, and livestock supplements

The rise in global population is projected to reach 8.5 billion by 2030 and 9.8 billion people by 2050 from 7.6 billion people (global population by 2017) according to the 2017 revised UN Department of Economic and Social Affairs (UNDESA) report [68], which pressures the world to find sustainable and sufficient food sources [69]. Animal and fish raising is regarded as one channel toward food security and nutrition. Some people worldwide rely on livestock and fish as sources of proteins and other nutritional components. There is a need for enough quantity, and high-quality feeds, particularly protein-rich feed to sustain animal food production. Unfortunately, conventional animal and fish feed production and availability are affected by climate change and environmental degradation. The promotion of new alternative nutrient-rich and eco-friendly feed sources is a crucial strategy to sustain animal and fish’ production.

Algal resources are one of the new sustainable feed resources that can supplement conventional feed due to its excellent nutrient compounds [70]. Algae are considered as a promising novel animal and fish feed with essential components for enhancement of animal growth, nutrients utilization, weight gaining, fertility, and good health [71]. In other words, the algae can produce numerous nutrients and biological active biomolecules content that can fulfill all nutritional and growth criteria for aquaculture and animal feed [72]. Therefore, algal resources are potential renewable sources to complement conventional ingredients in aquaculture and animal feed due to their associated advantages [73]. Algae produce high biomass productivity compared to other feed’s sources, high-quality contents such as high proteins, polyunsaturated fatty acids, vitamins, minerals, and pigments sources. Besides that, there are more health benefits other than nutrition such as immune defense, pharmacological, and biological activities including antioxidant, anti-inflammatory, etc.

For instance, Spirulina and/or Chlorella intake, as animal feed, has exhibited the improvement in animal health and productivity due to its nutrient-rich and bioactive compounds content with several biological functions [72,74]. Tibbetts, Mann and Dumas [72] highlighted that the biochemical (nutritional and bio-functional) composition profiles of Chlorella vulgaris are essential for aquaculture and animal feed. Spirulina is widely used in feed supplements due to its excellent nutrient compounds and digestibility because it does not contain cellulose in its cell wall and it has a small amount of carbohydrate [40].

The improvement of aquaculture and animal feeding strategy with algal resources will enrich the quality and safety of animal-derived foods due to their therapeutic effects over and above nutritional effects [75]. Ample integration of algal-derived feed and phagocytes will promote immune stimulants for Aquaculture Health Management and sustainability [76, 77]. Algal-derived feed can act as immune stimulants due to their several components with various health benefits including polyphenols, polypeptides, and alkaloids. These new approaches in aquaculture and hatchery will contribute to the replacement of traditional practices mainly based on the utilization of animal wastes, antibiotics, and other antimicrobial agents (Figure 6). Moreover, the microalgae cultivation is a promising process to treat the aquaculture wastewater and micro algal biomass production; thus, in turn, may be used as feed [78].

Several works revealed that Spirulina feed supplement in poultry reduces the cholesterol of egg yolk and increases the yolk color due to carotenoid accumulation [79]. It improves the feed quality that, in turn, leads to the accumulation of essential nutrients in animal meats. In case the animals are fed an unbalanced nutrient diet, for example, starchy feed, theyget fat, but the derived meat does not contain essential nutrients needed by the human body. The utilization of algal resources in aquaculture and animal feeds is not new, because it started in 1910 by Allen and Nelson who cultivated Chlorella sp. for aquaculture purpose [80]. The utilization of algae in aquaculture and animal feed can also be linked to the eradication of antibiotic resistance. The utilization of antibiotics as infection preventers and growth factors is one cause of antibiotic resistance, where humans can interact with their effects through the food chain.

The macro algae, also known as seaweed, are a source of sulfated polysaccharides that help animals to be healthier. The utilization of seaweeds animal feed is not only regarded as the availability of feeds, it has been proven that it can also reduce the amount of methane released by an animal, but more in-depth researches are necessary to elucidate the mechanism governing the mitigation of ruminal methane production and seaweeds as feed ingredients [81]. For example, one scientific study conducted in Australia reported that 2 percent of Asparagopsis Taxiformis (red algae) of the cow’s diet was effective in reducing cows’ methane emissions by 99 percent [82]. The utilization of algal resources as feed will also contribute to environmental protection by reducing gas emissions because livestock is also responsible for some percentage of all green gas emissions each year [83]. Utilization of algal-derived feed is an alternative that can be used to keep the animal and fish healthy; thus, lead to a reduction in the number of antibiotics to be added to the feed. Therefore, there is a necessity for new scientific studies to prove the replacement of antibiotics with algal derived feeds. The complete replacement of the use of antibiotics by the use of algal resources as feed and prophylactic grow factor can be a promising way to eradicate antibiotic resistance.

Algae for waste and wastewater treatment, bioenergy, and industrial feedstock

Today’s global population growth leads to high consumption accompanied by wastes production, depletion of natural resources, environmental degradation [84], and call for a quick change for sustainable progress. The increase of global population has also implicated the tremendous increase in the transportation fleet worldwide and petroleum as a primary energy source is depleting [85]. Climate changes such as global warming are the environmental issue associated with fossil fuel utilization; where the burning of fossil fuels raises the atmospheric carbon dioxide [86]. Therefore, biological carbon sequestration is a new algal resources-based technology, which is regarded as most promising, cost-effective and eco-friendly means of significantly reducing CO2, and other green gases (including NOX, SOX) emissions in the energy industry [14,85-88]. Algal derived biofuels production is the most promising and environmentally friendly energy production because algal resources are cultivated and harvested all year round by combining different cultivation modes, which make algal resources ubiquitous and sustainable feedstock. This mode of alternation could ensure the industries more security of supply of feedstocks. Algal biomass feedstock can be converted into a broad range of algal-derived products, including biofuels and other high valued products. Therefore, several industrial fields are urged to explore algal resources as sustainable and environmentally friendly feedstock [89,90].

Algal resources are regarded as renewable sources of biofuels due to the potential of substantial lipid accumulation [91]. For instance, Botryococcus sp. is well-known for the potential for significant lipid accumulation from wastewater [92], where 85% of Botryococcus braunii dry weight can be long-chain hydrocarbons. Subsequently, under eco-friendly technology, algal oils are converted into some biofuels such as bio-diesel, bio-hydrogen, and bio-methane [90].

Recent studies have revealed that algal bioenergy production is becoming more economical and eco-friendly due to the new mode of cultivation in different types of wastes and wastewater [92,93]. The algae cultivation using nutrients from wastes and wastewater is one mode of bioremediation, known as phycoremediation of both organic and inorganic pollutants [91,94-96]. For instance, Ganeshkumar, Subashchandrabose, Dharmarajan, Venkateswarlu, Naidu and Megharaj [97] investigated the efficiency in nutrient removal and lipid production by using Chlorella sp. grown in mixed wastewater from piggery and winery; the results showed that a mixed piggery and winery wastewater is a cost-effective approach for bioremediation and algal biomass production with a high amount of biofuel yield [97]. In this case, algal resources play a dual role, which is energy production coupled with bioremediation, and vice-versa [91,95,96]. Contrary to fossil fuel production, which is one cause of climate change and environmental problems such as air pollution that is harmful to both public health and ecosystem.

The integration of algae and bioenergy carbon capture and storage is one good example of promising new technology for global sustainability and sustainable algal biomass production as algal resources exploitation [98]. The Bioenergy Carbon Capture and Storage (BECCS), as a promising negative-emissions approach, but still requires the arable land and freshwater and can be unviable and cause competition with food production. The reason why, Beal, Archibald, Huntley, Greene and Johnson [98] proposed and conducted a study on integrating Algae with Bioenergy Carbon Capture and Storage (ABECCS) by replacing soy cropland with eucalyptus forests used for BECCS that provides marine algae with carbon dioxide, heat, and electricity. The results from Beal, Archibald, Huntley, Greene and Johnson [98] revealed that the integrated system on 2800-ha facility, without increasing freshwater, produced as much high-quality protein as soy; also the system generated additional economically benefits, which are 61.5 TJ of electricity while sequestering 29,600 t of carbon dioxide per year [98].

It is evident that human activities will continue dramatically to increase with global population growth [99]. Human activities, including industrialization, are the main cause of environmental degradation [87]. Therefore, there is urgently a need for promoting environmentally friendly and cost-effective technologies for wastes and wastewater treatment for environmental sustainability. Wastewater is another current environmental sustainability issue but is getting a promising solution, for its capacity to harbor a large number of algae. The nutrients in waste and wastewater are a suitable raw material for algal biomass and production of high-value products [100], while at the same time the algae can remove pollutants in water bodies, which is a crucial role in environmental bioremediation. Algae have proven potential in assimilating, for their survival, a significant amount of nutrients that would cause eutrophication in water bodies and carry out a wide task in the treatment of wastewater such as removal of other pollutants like heavy metals, Chemicals, among others from agro-industrial, pharmaceutical, and textile dye wastewaters [101].

Although chemical and physical based technologies have been widely used to remove nutrients and treat wastewater in general, they are highly energy intensive and consume large amounts of chemicals, making them costly and less environmentally friendly processes [102]. However, algae-based technologies potentially treat wastewaters by removing nutrients in an inexpensive and environmentally friendly way with added resource recovery, recycling, and feedstock production as added benefits [103]. Mainly, this is a thriving technology, on the one hand, because microalgae biomass produced after treatment is of great value as it can be used for biofuels, fertilizers, and pharmaceutical production [104]. On the other hand, it reduces energy use because when integrated into the conventional activated sludge system, the algae-bacteria symbiosis replace the aeration phase which generally cost more than 60% of total energy spent in wastewater treatment [105]. Through photosynthesis, algae provide the oxygen needed by bacteria to biodegrade organic pollutants and capture CO2 released by the bacterial activity, which also reduces the carbon footprint.

Algal resources can naturally grow in waterbodies due to the presence of various nutrients and can form algal blooms in eutrophic water bodies [106], causing environmental sustainability issues. Such algal bloom is a threat to ecosystem functioning in cases it is not exploited for other purposes [107]. Algal resources exploitation will strengthen mitigation of eutrophication. In other words, the use of algal resources exploitation can hasten the removal of excess nutrients into water bodies to mitigate eutrophication.

Algae for bio-fertilizers and agriculture

Safe and sustainable agriculture is among the priorities to achieve food security and nutrition, and environmental sustainability. Besides crop production, agricultural practices are associated with ecosystem services including water quality, soil quality, nutrient cycling, and biodiversity conservation [108]. Unsustainable agricultural practices, such as deforestation, are among the leading causes of the negative environment and ecosystem problems including soil erosion and degradation, and pollution [109]. In other words, ecosystem services and agricultural practices are concomitant in some ways because the ecosystem services also affect agricultural crop production. In turn, environmental degradation affects crops production negatively. In the case of agriculture practices are not handled by green technology; they are inevitably threats to environmental sustainability.

There will be increasing pressure on the world to provide enough goods and services to the increasing population [42,69]. Food security and nutrition, and human well-being are among the basic needs to satisfy the global human quality of life [110]. Algal resources provide sustainable feedstocks that are useful in sustainable agriculture and industry [111]. Byproducts from algal biofuels production can also be used in agriculture as bio-fertilizers and feeds [69]. New technologies of large-scale algae cultivation by using wastewater as a source of the nutrient without requiring arable land and fresh water are considered as a promising approach to environmental sustainability. These new technologies for algal biomass production can be used as a bioremediation approach for removing and recycling nutrients from wastewater into algae-based bio-fertilizers [112]. Algal biomass enhances soil fertility as a bio-fertilizer source by improving soil phyco-chemical characteristics including mineral nutrient enhancement [90]. Furthermore, treated water from wastewater treatment can be utilized in agriculture for irrigation. Algae can also produce Aminolevulinic Acid (ALA) that has many applications in different fields including agriculture as a natural herbicide, insecticide, and a growth-promoting factor for plants [113,114].

Conclusion

The algal derived resources synthesize broad nutritional and bio-functional compounds with several applications in various industrial fields for sustainable development. Algal derived resources, as sustainable resources, should be optimally exploited for resolving global challenges including human pathogens [115] and food security and nutrition. The exploitation of algal resources for resolving the global burdening health challenges need to urgently increase willingness in innovation and technology, as well as the educational way for more understanding of potentials of algal-derived products and eradication of negative connotation toward their utilization, especially in developing countries where most burdening challenges are still at high levels.

Future Perspectives

Algal derived foods, and food additives can be effective and adequate natural products to enrich human nutrient-rich health foods if is fully exploited and integrated into food security and nutrition, especially for the poorest population that lacks nutrient-rich food and dietary diversity, thus leading to malnutrition and food-induced diseases. Enriched food will promote body self-protection and self-healing capacities leading to a healthy life.

This review suggests that agencies in charge of algal exploitation should be established, in each country worldwide, for assurance of full exploitation and safety services. Notably, the developing countries should provide a budget for the exploitation of algal resources in several industrial sectors, including food, feed, agriculture and aquaculture, pharmaceutical, environment management, and bioenergy. The integration of algal exploitation in those areas will play pivotal roles in solving the food, energy, environmental crisis prevailing in the world, particularly in developing countries. Besides human health benefits, algal resources play a role in animal and fish feeds, as well as environmental bioremediation. Several industries likely consider algal resources as ubiquitous, sustainable, and affordable feedstock, and they are promoting related research and development for production efficiency and cost-effective.

Availability of such feedstock will play a significant role in the industries’ development. The various industries also need to partner among them for the full exploitation and take the advantages of the benefits of algal-derived byproduct. This approach is a key strategy for the transformation of algal resources into useful assets and to bring algal resources into the human quality of life arena. In this line, researchers, engineers, and stakeholders from various fields have to form alliances to find sustainable solutions to the current world most pressing health challenges. That collaboration will promote the mutual sharing of knowledge in algal resources exploitation for green growth and sustainable development.

Even though algal resources have many advantages; they also have some drawbacks. Some species can produce biogenic and non-biogenic toxins [69]. Therefore, the algal species and production related technology should be selected based on end products and the targeted application, as depicted in (Figure 4). Some regulatory standard, including quality standards, should be established and monitored to prevent any incident that may be caused by algal resources exploitation.

Highlights

·         Algal resources are prominent sustainable resources for broad range applications.

·         Applications of Algae-derived products are the resolution of global pressing health challenges.

·         Algal resources inputs that can contribute to the achievement of a green economy and sustainable development.

·         Amply exploitation of algal resources contributes to the potential change in diet and production.

·         Phycoremediation is among novel technology that can contribute to environmental sustainability. 

Declarations of Conflict of interest:  None 

Acknowledgment

This work was financed by the Natural Science Foundation of China [No. 21776232, and No. 21736009]; the Natural Science Foundation of Fujian Province of China [No. 2018J0101]; the Natural Science Foundation of Fujian Provincial University Youth Key Program of China [No. JZ160401]; and the Science and Technology Program of Xiamen, China [No. 3502Z20173018]. We are grateful for Yunnan Green A Biological Project Co., Ltd for the permission to use their information.


Figure 1: A conceptual schematic diagram of the input of algal resources in the achievement of Zero hunger and Good health and well-being goals as ones of the keys for sustainable development.



Figure 2: Channels toward human antibiotic resistance.



Figure 3: Algal derived functional foods and nutraceuticals, potential, suitable, and adequate superfood for preventing and controlling various diseases, especially chronic diseases.



Figure 4: Flowsheet of algal resources production process and applications.



Figure 5: Main nutritional composition of a typical product of Spirulina from Yunnan Green A Biological Project Co., Ltd. located in Kunming, Yunnan, China. a. a copy from the company, b. scanned from package box with permission from the company.



Figure 6: Novel alternatives for aquaculture/hatchery safety and sustainability.




1.       UNCED, Report of the United Nations Conference on Environment and Development, A/CONF.151/26 (Vol. I-V), 1992.

2.       Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, et al. (2006) Disease control priorities in developing countries, second ed., The International Bank for Reconstruction and Development / The World Bank, Washington DC.

3.       Campbell BM, Vermeulen SJ, Aggarwal PK, Corner-Dolloff C, Girvetz E, et al. (2016) Reducing risks to food security from climate change. Global Food Security 11: 34-43.

4.       UNCSD, Report of the United Nations Conference on Sustainable Development, A/CONF.216/16, 2012.

5.       UNGA, General Assembly Resolution, The future we want, A/RES/66/288 2012.

6.       FAO, IFAD, UNICEF, WFP, WHO, The State of Food Security and Nutrition in the World 2017. Building resilience for peace and food Security Rome, 2017.

7.       N. National Cancer Institute, Cancer Statistics Natinal Cancer Institute U.S. Department of Health and Human Services, USA, 2017.

8.       Choukem SP, Mbanya JC (2018) Diabetes Academy Africa: training the next generation of researchers in sub-Saharan Africa. The Lancet Global Health 6: e371-e372.

9.       UNESCO, The Scientific Advisory Board of the United Nations Secretary-General, 2013.

10.    Magdoff F (2013) Global Resource Depletion Is Population the Problem?. Monthly Review: 64.

11.    Zielińska MA, Wesołowska A, Pawlus B, Hamułka J (2017) Health effects of carotenoids during pregnancy and lactation. Nutrients: 9.

12.    Estime B, Ren D, Sureshkumar R (2017) Cultivation and energy efficient harvesting of microalgae using thermoreversible sol-gel transition. Scientific Reports 7: 40725.

13.     Zhu L (2015) Biorefinery as a promising approach to promote microalgae industry: An innovative framework. Renewable and Sustainable Energy Reviews 41: 1376-1384.

14.     Borowitzka MA (2013) High-value products from microalgae-their development and commercialisation. J Appl Phycol 25: 743-756.

15.    Raiten DJ, Aimone AM (2017) The intersection of climate/environment, food, nutrition and health: crisis and opportunity. Curr Opin Biotechnol 44: 52-62.

16.    Wongsuvan G, Wuthiekanun V, Hinjoy S, Day NPJ, Limmathurotsakul D, et al. (2018) Antibiotic use in poultry: A survey of eight farms in Thailand. Bull. W.H.O 96: 94-100.

17.    Good AG, Beatty PH (2011) Fertilizing Nature: A Tragedy of Excess in the Commons. PLoS Biol 9: e1001124.

18.    Anthony AR (2009) Preventing Diet Induced Disease: Bioavailable Nutrient-Rich, Low-Energy-Dense Diets. Nutrition and Health 20: 135-166.

19.    Alassali A, Cybulska I, Brudecki GP, Farzanah R, Thomsen MH, et al. (2016) Methods for upstream extraction and chemical characterization of secondary metabolites from algae biomass. Advanced Techniques in Biology & Medicine 4: 1-16.

20.    Alam MA, Wang Z, Yuan Z (2017) Generation and Harvesting of Microalgae Biomass for Biofuel Production, in: B.N. Tripathi, D. Kumar (Eds.) Prospects and Challenges in Algal Biotechnology. Springer Singapore, Singapore: 89-111.

21.    Nedumaran T, Arulbalachandran D (2015)Seaweeds: A Promising Source for Sustainable Development. Environmental Sustainability, Springer: pp. 65-88.

22.    Beetul K, Gopeechund A, Kaullysing D, Mattan-Moorgawa S, Puchooa D, et al. (2016) Challenges and Opportunities in the Present Era of Marine Algal Applications, in: N. Thajuddin, D. Dhanasekaran (Eds.) Algae - Organisms for Imminent Biotechnology, InTech, Rijeka, Ch. 10.

23.    El Gamal AA (2010) Biological importance of marine algae. Saudi Pharmaceutical Journal 18: 1-25.

24.    Borowitzka MA (1995) Microalgae as sources of pharmaceuticals and other biologically active compounds. J Appl Phycol 7: 3-15.

25.    Vijayakumar S, Menakha M (2015) Pharmaceutical applications of cyanobacteria-A review. Journal of Acute Medicine 5: 15-23.

26.    Borowitzka MA (1999) Commercial production of microalgae: ponds, tanks, tubes and fermenters. J. Biotechnol 70: 313-321.

27.    Kovač D, Babić O, Milovanović I, Mišan A, Simeunović J, et al. (2017) The production of biomass and phycobiliprotein pigments in filamentous cyanobacteria: the impact of light and carbon sources. Appl Biochem Microbiol 53: 539-545.

28.    Nagaraja Y, Biradar C, Manasa K, Venkatesh H (2014) Production of biofuel by using micro algae (Botryococcus braunii). International Journal of Current Microbiology and Applied Sciences 3: 851-860.

29.    Pulz O (2001) Photobioreactors: production systems for phototrophic microorganisms. Appl Microbiol Biotechnol 57: 287-293.

30.    Research and Markets (2017-2022) Algae Products Market- Global Opportunity Analysis And Industry Forecast Research and Markets The world's largest market resarch store, Research and Markets Dublin, Ireland 2018.

31.    Dewapriya P, Kim Sk (2014) Marine microorganisms: An emerging avenue in modern nutraceuticals and functional foods. Food Res Int 56: 115-125.

32.    Vaz BdS, Moreira JB, Morais MGd, Costa JAV, et al. (2016) Microalgae as a new source of bioactive compounds in food supplements. Current Opinion in Food Science 7: 73-77.

33.    Caporgno MP, Mathys A (2018) Trends in Microalgae Incorporation Into Innovative Food Products With Potential Health Benefits. Frontiers in nutrition 5: 1-10.

34.    Maizatul AY, Radin Mohamed RMS, Al-Gheethi AA, Hashim MKA (2017) An overview of the utilisation of microalgae biomass derived from nutrient recycling of wet market wastewater and slaughterhouse wastewater. International Aquatic Research 9: 177-193.

35.    Wells ML, Potin P, Craigie JS, Raven JA, Merchant SS, et al. (2017) Algae as nutritional and functional food sources: revisiting our understanding. J Appl Phycol 29: 949-982.

36.    Chacón-Lee TL (2010) González-Mariño GE, Microalgae for “Healthy” Foods-Possibilities and Challenges. Comprehensive Reviews in Food Science and Food Safety 9: 655-675.

37.    Ranga RA, Vijaya RD, Ravishankar G (2017) Secondary Metabolites from Algae for Nutraceutical Applications. Nov Tech Nutri Food Sci 1: NTNF.000503.

38.    Soheili M, Khosravi-Darani K (2011) The potential health benefits of algae and micro algae in medicine: a review on Spirulina platensis. Current Nutrition & Food Science 7: 279-285.

39.    Soltani N, Latifi Am, Alnajar N, Dezfulian M, Shokarvi S, et al. (2016) Biochemical and Physiological Characterization of Tree Microalgae spp. as Candidates for Food Supplement. Journal of Applied Biotechnology Reports 377-381%V 373.

40.    Seyidoglu N, Inan S, Aydin C (2017) A Prominent Superfood: Spirulina platensis, in: N. Shiomi, V. Waisundara (Eds.) Superfood and Functional Food - The Development of Superfoods and Their Roles as Medicine, InTech, Rijeka, pp. Ch. 01.

41.    Bouis HE, Saltzman A (2017) Improving nutrition through biofortification: A review of evidence from HarvestPlus, 2003 through 2016. Global Food Security 12: 49-58.

42.    Hayes M (2018) Food Proteins and Bioactive Peptides: New and Novel Sources, Characterisation Strategies and Applications. Foods 7: 38-41.

43.    Pham-Huy LA, He H, Pham-Huy C (2008) Free Radicals, Antioxidants in Disease and Health. International Journal of Biomedical Science IJBS 4: 89-96.

44.    Raposo MFdJ, de Morais AMMB, de Morais RMSC (2015) Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases. Mar Drugs 13: 5128-5155.

45.    Niu YJ, Zhou W, Guo J, Nie ZW, Shin KT, et al. (2017) C-Phycocyanin protects against mitochondrial dysfunction and oxidative stress in parthenogenetic porcine embryos. Scientific Reports 7: 16992.

46.    Cámara M, De Cortes Sánchez-Mata M, Fernández-Ruiz V, Cámara RM, Manzoor S, et al. (2013) Lycopene: A review of chemical and biological activity related to beneficial health effects, in: R. Atta ur (Ed.) Stud. Nat Prod Chem: 383-426.

47.    Holzapfel NP, Holzapfel BM, Champ S, Feldthusen J, Clements J, et al. (2013) The Potential Role of Lycopene for the Prevention and Therapy of Prostate Cancer: From Molecular Mechanisms to Clinical Evidence. International Journal of Molecular Sciences 14: 14620-14646.

48.    Gulati K, Anand R, Ray A (2016) Chapter 16 - Nutraceuticals as Adaptogens: Their Role in Health and Disease A2 - Gupta, Ramesh C, Nutraceuticals, Academic Press, Boston: 193-205.

49.    Azeemi STY, Raza SM, Yasinzai M, Samad A (2009) Effect of Different Wavelengths on Superoxide Dismutase. Journal of Acupuncture and Meridian Studies 2: 236-238.

50.    Abdel-Aal ESM, Akhtar H, Zaheer K, Ali R (2013) Dietary Sources of Lutein and Zeaxanthin Carotenoids and Their Role in Eye Health. Nutrients 5: 1169-1185.

51.    Fiedor J, Burda K (2014) Potential Role of Carotenoids as Antioxidants in Human Health and Disease. Nutrients 6: 466-488.

52.    Andrade LM, Andrade CJ, Dias M, Nascimento CA, Mendes MA, et al. (2018) Chlorella and Spirulina Microalgae as Sources of Functional Foods, Nutraceuticals, and Food Supplements; an Overview. MOJ Food Processing and Technology: 61-14.

53.    Scholz-Ahrens KE, Ade P, Marten B, Weber P, Timm W, et al. (2007) Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. The Journal of nutrition 137: 838S-846S.

54.    Patel S, Goyal A (2012) The current trends and future perspectives of prebiotics research: a review. 3 Biotech 2: 115-125.

55.    Schnekenburger M, Diederich M (2015) Chapter 18 - Nutritional Epigenetic Regulators in the Field of Cancer: New Avenues for Chemopreventive Approaches A2 - Gray, Steven G, Epigenetic Cancer Therapy, Academic Press, Boston: 393-425.

56.    Niamh M (2018) Spirulina finds success in Dutch start-up's algae chocolate News & Analysis on Food & Beverage Development William Reed Business Media Ltd, England.

57.    IFP Editorial Staff, Iranian Scientists Produce Sweets for Diabetics from Seaweeds, News and Views form Iran and the World Iran Front Page News, Iran 2017.

58.    Burcu A, Ezgi A, Oya I, Gülsün Ö, Ebru K, et al. (2016) Nutritional and Physicochemical Characteristics of Bread Enriched with Microalgae Spirulina platensis. International Journal of Engineering Research and Applications 6: 30-38.

59.    Lucas BF, Morais MGD, Santos TD, Costa JAV, et al. (2018) Spirulina for snack enrichment: Nutritional, physical and sensory evaluations. LWT - Food Science and Technology 90: 270-276.

60.    Thomas NV, Kim SK (2011) Potential pharmacological applications of polyphenolic derivatives from marine brown algae. Environ. Toxicol. Pharmacol 32: 325-335.

61.    Mimouni V, Ulmann L, Pasquet V, Mathieu M, Picot L, et al. (2012) The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest. Curr. Pharm. Biotechnol 13: 2733-2750.

62.    Bhatia S, Rathee P, Sharma K, Chaugule BB, Kar N, et al. (2013) Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis. International Journal of Biological Macromolecules 57: 50-56.

63.    Finamore A, Palmery M, Bensehaila S, Peluso I (2017) Antioxidant, Immunomodulating, and Microbial-Modulating Activities of the Sustainable and Ecofriendly Spirulina. Oxidative Medicine and Cellular Longevity: 3247528.

64.    Shannon E, Abu-Ghannam N (2016) Antibacterial Derivatives of Marine Algae: An Overview of Pharmacological Mechanisms and Applications. Mar Drugs 14: 81.

65.    Torres FAE, Passalacqua TG, Velásquez AMA, de Souza RA, Colepicolo P, et al. (2014) New drugs with antiprotozoal activity from marine algae: a review. Revista Brasileira de Farmacognosia 24: 265-276.

66.    Martins A, Vieira H, Gaspar H, Santos S (2014) Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success. Mar Drugs 12: 1066-1101.

67.    Noguchi N, Maruyama I, Yamada A, (2014) The Influence of Chlorella and Its Hot Water Extract Supplementation on Quality of Life in Patients with Breast Cancer. Evidence-Based Complementary and Alternative Medicine: 7.

68.    UNDESA, World population projected to reach 9.8 billion in 2050, and 11.2 billion in 2100 – says UN, UN Department of Economic and Social Affairs (UN DESA), New York 2015.

69.    Lum KK, Kim J, Lei XG (2013) Dual potential of microalgae as a sustainable biofuel feedstock and animal feed. Journal of Animal Science and Biotechnology 4: 53.

70.    Dajana JK, Jelica BS, Olivera BB, Aleksandra CM, Ivan LM (2013) Algae in food and feed. Food & Feed Research 40: 21-32.

71.    Camacho-Rodríguez J, Macías-Sánchez MD, Cerón-García MC, Alarcón FJ, Molina-Grima E (2017) Microalgae as a potential ingredient for partial fish meal replacement in aquafeeds: nutrient stability under different storage conditions. J Appl Phycol 30: 1049-1059.

72.    Tibbetts SM, Mann J, Dumas A (2017) Apparent digestibility of nutrients, energy, essential amino acids and fatty acids of juvenile Atlantic salmon (Salmo salar L.) diets containing whole-cell or cell-ruptured Chlorella vulgaris meals at five dietary inclusion levels. Aquaculture 481: 25-39.

73.    Yaakob Z, Ali E, Zainal A, Mohamad M, Takriff MS (2014) An overview: biomolecules from microalgae for animal feed and aquaculture. Journal of Biological Research 21: 6.

74.    Radhakrishnan S, Saravana Bhavan P, Seenivasan C, Shanthi R, Muralisankar T (2014) Replacement of fishmeal with Spirulina platensis, Chlorella vulgaris and Azolla pinnata on non-enzymatic and enzymatic antioxidant activities of Macrobrachium rosenbergii. The Journal of Basic & Applied Zoology 67: 25-33.

75.    Wang W, Sun J, Liu C, Xue Z (2017) Application of immunostimulants in aquaculture: current knowledge and future perspectives. Aquacult Res 48: 1-23.

76.    Martin SAM, Król E (2017) Nutrigenomics and immune function in fish: new insights from omics technologies. Dev. Comp. Immunol 75: 86-98.

77.    Barman D, Nen P, Mandal D, Kumar V (2013) Immunostimulants for aquaculture health management. J Marine Sci Res Dev 3: 1-16.

78.    Guldhe A, Ansari FA, Singh P, Bux F (2017) Heterotrophic cultivation of microalgae using aquaculture wastewater: A biorefinery concept for biomass production and nutrient remediation. Ecol Eng 99: 47-53.

79.    Belay A, Kato T, Ota Y (1996) Spirulina (Arthrospira): potential application as an animal feed supplement. J. Appl Phycol 8: 303-311.

80.    Preisig HR, Andersen RA (2005) Historical review of algal culturing techniques, in: R.A. Andersen (Ed.) Algal culturing techniques, Academic Press, London, UK, 1-12.

81.    Maia MRG, Fonseca AJM, Oliveira HM, Mendonça C, Cabrita ARJ (2016) The Potential Role of Seaweeds in the Natural Manipulation of Rumen Fermentation and Methane Production. Scientific Reports 6: 32321.

82.    Kesteven S (2016) Feeding cows seaweed could slash global greenhouse gas emissions, researchers say. in: A.N. team (Ed.) ABC News ABC North Queensland Australia.

83.    Gillespie S, Bold MVD (2017) Agriculture, Food Systems, and Nutrition: Meeting the Challenge. Global Challenges 1: 1600002.

84.    Bleakley S, Hayes M (2017) Algal Proteins: Extraction, Application, and Challenges Concerning Production. Foods 6: 33.

85.    Chia SR, Chew KW, Show PL, Yap YJ, Ong HC, et al. (2018) Analysis of Economic and Environmental Aspects of Microalgae Biorefinery for Biofuels Production: A Review. Biotechnology Journal 13: 1-10.

86.    Sudhakar K, Suresh S, Premalatha M (2011) An overview of CO2 mitigation using algae cultivation technology. Int J Chem Res 3: 110-117.

87.    Brar A, Kumar M, Vivekanand V, Pareek N (2017) Photoautotrophic microorganisms and bioremediation of industrial effluents: current status and future prospects. 3 Biotech 7: 7-18.

88.    Baldev E, Mubarakali D, Saravanakumar K, Arutselvan C, Alharbi NS, et al, (2018) Unveiling algal cultivation using raceway ponds for biodiesel production and its quality assessment. Renewable Energy 123: 486-498.

89.    Matos AP (2017) The Impact of Microalgae in Food Science and Technology. JAOCS Journal of the American Oil Chemists' Society 94: 1333-1350.

90.    Singh JS, Kumar A, Rai AN, Singh DP (2016) Cyanobacteria: A Precious Bio-resource in Agriculture, Ecosystem, and Environmental Sustainability. Frontiers in Microbiology 7: 529.

91.    Ravindran B, Gupta S, Cho WM, Kim J, Lee S, et al. (2016) Microalgae Potential and Multiple Roles-Current Progress and Future Prospects-An Overview. Sustainability 8: 1215.

92.    Shen L, Ndayambaje JD, Murwanashyaka T, Cui W, Manirafasha E, et al. (2017) Assessment upon heterotrophic microalgae screened from wastewater microbiota for concurrent pollutants removal and biofuel production. Bioresour. Technol 245: 386-393.

93.    Fernández-Linares LC, Barajas CG, Páramo ED, Corona JAB (2017) Assessment of Chlorella vulgaris and indigenous microalgae biomass with treated wastewater as growth culture medium. Bioresour Technol 244: 400-406.

94.    Chekroun KB, Baghour M (2013) The role of algae in phytoremediation of heavy metals: a review. J Mater Environ Sci 4: 873-880.

95.    Jatav KS, Singh RP (2015) Phytoremediation Using Algae and Macrophytes: II, in: Ansari AA, Gill SS, Gill R, Lanza GR, Newman L (Eds.) Phytoremediation: Management of Environmental Contaminants, Volume 2, Springer International Publishing, Cham: 291-296.

96.    Hwang JH, Church J, Lee SJ, Park J, Lee WH (2016) Use of Microalgae for Advanced Wastewater Treatment and Sustainable Bioenergy Generation. Environmental Engineering Science 33: 882-897.

97.    Ganeshkumar V, Subashchandrabose SR, Dharmarajan R, Venkateswarlu K, Naidu R, et al. (2018) Use of mixed wastewaters from piggery and winery for nutrient removal and lipid production by Chlorella sp. MM3. Bioresour. Technol 256: 254-258.

98.    Beal CM, Archibald I, Huntley ME, Greene CH, Johnson ZI (2018) Integrating Algae with Bioenergy Carbon Capture and Storage (ABECCS) Increases Sustainability. Earth's Future 6: 524-542.

99.    UNWWDR (2015) The United Nations World Water Development Report 2015: Water for a Sustainable World.

100. Santhosh S, Dhandapani R, Hemalatha N (2016) Bioactive compounds from Microalgae and its different applications- a review. Advances in Applied Science Research 7: 153-158.

101. Wang Y, Ho SH, Cheng CL, Guo WQ, Nagarajan D, et al. (2016) Perspectives on the feasibility of using microalgae for industrial wastewater treatment. Bioresour. Technol 222: 485-497.

102. Christenson L, Sims R (2011) Production and harvesting of microalgae for wastewater treatment, biofuels, and bioproducts. Biotechnol Adv 29: 686-702.

103. Abdel-Raouf N, Al-Homaidan AA, Ibraheem IBM (2012) Microalgae and wastewater treatment. Saudi Journal of Biological Sciences 19: 257-275.

104. Bilad MR, Vandamme D, Foubert I, Muylaert K, Vankelecom IFJ (2012) Harvesting microalgal biomass using submerged microfiltration membranes. Bioresour. Technol 111: 343-352.

105. Hoffmann JP (1998) Wastewater Treatment With Suspended And Nonsuspended Algae. J Phycol 34: 757-763.

106. Waters S, Webster-Brown JG (2016) The use of a mass balance phosphorus budget for informing nutrient management in shallow coastal lakes. Journal of Hydro-environment Research 10: 32-49.

107. Heisler J, Glibert P, Burkholder J, Anderson D, Cochlan W, et al. (2008) Eutrophication and Harmful Algal Blooms: A Scientific Consensus. Harmful Algae 8: 3-13.

108. Dale VH, Polasky S (2007) Measures of the effects of agricultural practices on ecosystem services. Ecol. Econ 64: 286-296.

109. Adomako T, Ampadu B (2015) The Impact of Agricultural Practices on Environmental Sustainability in Ghana: A Review. Journal of Sustainable Development 8: 70-85.

110. Diener E, Suh E (1997) Measuring Quality of Life: Economic, Social, and Subjective Indicators. Social Indicators Research 40: 189-216.

111. Prasanna R, Sood A, Ratha SK, Singh PK (2014) Cyanobacteria as a “green” option for sustainable agriculture, in: K.S. Naveen, K.R. Ashwani, J.S. Lukas (Eds.) Cyanobacteria: An Economic Perspective, John Wiley & Sons, Ltd, Oxford, UK. 145-166.

112. Solovchenko A, Verschoor AM, Jablonowski ND, Nedbal L (2016) Phosphorus from wastewater to crops: An alternative path involving microalgae. Biotechnol Adv 34: 550-564.

113. Sasaki K, Watanabe M, Tanaka T, Tanaka T (2002) Biosynthesis, biotechnological production and applications of 5-aminolevulinic acid. Appl Microbiol Biotechnol 58: 23-29.

114. Liu S, Zhang G, Li X, Zhang J (2014) Microbial production and applications of 5-aminolevulinic acid. Appl Microbiol Biotechnol 98: 7349-7357.

115. Murphin Kumar PS, MubarakAli D, Saratale RG, Saratale GD, Pugazhendhi A, et al. (2017) Synthesis of nano-cuboidal gold particles for effective antimicrobial property against clinical human pathogens. Microb Pathog 113: 68-73.


Citation: Manirafasha E, Vangh AV, Murwanashyaka T, Rugabirwa B, Ndikubwimana T, et al. (2019) Algal Resources Exploitation for Green Economy and Sustainable Development: A Review. Adv Biochem Biotechnol 7: 1089. DOI: 10.29011/2574-7258.001089

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