Journal of Urology and Renal Diseases (ISSN: 2575-7903)

research article

A Randomized Controlled Trial was Conducted to Investigate the Effects of Adjustable Sodium Dialysis on Blood Pressure and Blood Pressure Variability during Dialysis

Yun-Qiang Zhang 1, Min-Jia Li 1, Sheng-Rong Li 1, Si-Yuan Zou 1, Dong-Mei Hong 1 and Xun Liu 2*

1Blood Purification Center, The Third Affiliated Hospital, Sun Yat-Sen University, Yuedong Hospital, Meizhou City, Guangdong province, China

2Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

*Corresponding author: Xun Liu, Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China

Received Date: 01 July, 2021 Accepted Date: 06 July, 2021 Published Date: 09 July, 2021


Objectives: To explore the effect of adjustable sodium dialysis mode on blood pressure and blood pressure variation rate in MHD patients.

Methods: 130 patients were included,In the experimental group(n=65) were treated with adjustable sodium dialysis. The dialysate sodium concentration decreased gradually from 141mmol/L at the beginning of dialysis to 135mmol/L 30min before dialysis, and 30min maintained sodium concentration 140mmol/L before the end of dialysis.The control group (n=65) were dialyzed with constant sodium 140mmol/L. Age, sex, height, weight after last dialysis, pre-dialysis weight, dry weight and interdialysis weight growth were measured at baseline and 1 month later, and the interdialysis weight growth rate, systolic blood pressure variation rate and diastolic blood pressure variation rate were calculated. The differences of related indexes between the two groups were compared between the baseline and after 1 month.

Results: After dialysis with adjustable sodium for one month, the coefficient of variation of systolic blood pressure in the experimental group was 7.06%±3.18%, which was significantly lower than that in the control group (8.97%±5.06%, P=0.011).

Conclusion: After one month of adjustable sodium dialysis, the coefficient of variation of systolic blood pressure in MHD patients can be reduced.


Adjustable sodium; Blood pressure; Coefficient of variation; Maintenance hemodialysis


ESRD: End-Stage Renal Disease; BPV: Blood Pressure Variability; CKD: Chronic Kidney Disease; CVD: Cardiovascular Disease; DBP: Diastolic Blood Pressure; MAP: Mean Arterial Pressure; SBP: Systolic Blood Pressure

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