Introduction: People with pre-diabetes are at increased risk to develop type 2 Diabetes Mellitus (DM) and cardiovascular diseases.
Behavioral lifestyle intervention may play an important role in slowing down, stop or even reverse the progression to type 2 DM.
The purpose of this study is exploring the epidemiological characteristics of prediabetes and assess the available knowledge about
the role of PE intervention on prediabetic adults.
Methodology: Narrative review was done through using academic database search. Fifty-one English online articles about the
effect of exercises on prediabetic adults have been included in the study.
Findings: Most studies agreed on positive effects of PE on glycemic status in prediabetic patients. However, some studies find
slight or even no effects of lifestyle modifications including PE on developing type 2 DM and other complications. Studies agreed
that, PE on both aerobic and resistance exercise adjusts cellular glucose uptake, improve insulin sensitivity, muscular and hepatic
glucose metabolism resulting in more glycemic control, which reverses many pathological factors related to the usual glycemic &
metabolic control and cardiopulmonary function. Substantial inconsistency in some studies could be explained by race, existing
comorbidities, individual physiological status and PE prescription.
Conclusion: This review suggests that PE may express a positive influence among prediabetic patients. However more
population-based studies with clinical trial design are needed taking into consideration many confounders including race, gender,
genetics, physiological status and PE training prescription.
Prediabetes; Impaired glucose tolerance test; Impaired fasting glucose; Physical exercise; Type 2 diabetes mellitus
ADA: American Diabetes Association; CVD: Cardiovascular Disease; DM: Diabetes Mellitus; HIIT: High Intensity Intermittent Training;
IDF: International Diabetes Federation; IEC: International Expert Committee; IFG: Impaired Fasting Glucose; IGT: Impaired Glucose Tolerance;
NDDG: National Diabetes Data Group; NICE: National Institute for Health Care Excellence; WHO: World Health Organization